Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment

Abstract

Background Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early-stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of people with these cancers. This is an update of a review originally published in 2007 and first updated in 2011. Objectives To determine which surgical treatment modalities for oral and oropharyngeal cancers result in increased overall survival, disease-free survival and locoregional control and reduced recurrence. To determine the implication of treatment modalities in terms of morbidity, quality of life, costs, hospital days of treatment, complications and harms.

Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries

“…One was reviewing public cancer registries during the 6-year period from 2002 to 2007, and the second was a cross-sectional survey among 111 oral cancer patients admitted to MGH alone during the 2-year period from 2006 to 2007. Almost all the cancer patients in this country were referred to YGH and (2004 and 2006), and these results are similar to those found in the worldwide data (2)(3)(4). Globally, oral cancer is considered to be the 8th to 14th most common cancer accounting for an estimated 3% of all cancers (5).…”

Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries

“…One was reviewing public cancer registries during the 6-year period from 2002 to 2007, and the second was a cross-sectional survey among 111 oral cancer patients admitted to MGH alone during the 2-year period from 2006 to 2007. Almost all the cancer patients in this country were referred to YGH and (2004 and 2006), and these results are similar to those found in the worldwide data (2)(3)(4). Globally, oral cancer is considered to be the 8th to 14th most common cancer accounting for an estimated 3% of all cancers (5).…”

Primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers: A longitudinal population study

“…Similar to previous published studies the majority of the cases were diagnosed in advanced stages 83% of patients were stage III or IV at time of diagnosis [1,9,13,16]. …”

Surgical Extent for Oral Cancer: Emphasis on a Cut-Off Value for the Resection Margin Status: A Narrative Literature Review

“…Many clinical studies have investigated the optimal resection margin or margin length (width) in oral cancer surgery [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. A recent meta-analysis of the resection margin size in oral squamous cell carcinoma (SCC) suggested that a 5 mm pathologic margin is the minimum acceptable value [ 42 ].…”

Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries

“…One was reviewing public cancer registries during the 6-year period from 2002 to 2007, and the second was a cross-sectional survey among 111 oral cancer patients admitted to MGH alone during the 2-year period from 2006 to 2007. Almost all the cancer patients in this country were referred to YGH and (2004 and 2006), and these results are similar to those found in the worldwide data (2)(3)(4). Globally, oral cancer is considered to be the 8th to 14th most common cancer accounting for an estimated 3% of all cancers (5).…”

Primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers: A longitudinal population study

“…Similar to previous published studies the majority of the cases were diagnosed in advanced stages 83% of patients were stage III or IV at time of diagnosis [1,9,13,16]. …”

Surgical Extent for Oral Cancer: Emphasis on a Cut-Off Value for the Resection Margin Status: A Narrative Literature Review

“…Many clinical studies have investigated the optimal resection margin or margin length (width) in oral cancer surgery [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. A recent meta-analysis of the resection margin size in oral squamous cell carcinoma (SCC) suggested that a 5 mm pathologic margin is the minimum acceptable value [ 42 ].…”

Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries

“…One was reviewing public cancer registries during the 6-year period from 2002 to 2007, and the second was a cross-sectional survey among 111 oral cancer patients admitted to MGH alone during the 2-year period from 2006 to 2007. Almost all the cancer patients in this country were referred to YGH and (2004 and 2006), and these results are similar to those found in the worldwide data (2)(3)(4). Globally, oral cancer is considered to be the 8th to 14th most common cancer accounting for an estimated 3% of all cancers (5).…”

Primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers: A longitudinal population study

“…Similar to previous published studies the majority of the cases were diagnosed in advanced stages 83% of patients were stage III or IV at time of diagnosis [1,9,13,16]. …”

Surgical Extent for Oral Cancer: Emphasis on a Cut-Off Value for the Resection Margin Status: A Narrative Literature Review

“…Many clinical studies have investigated the optimal resection margin or margin length (width) in oral cancer surgery [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. A recent meta-analysis of the resection margin size in oral squamous cell carcinoma (SCC) suggested that a 5 mm pathologic margin is the minimum acceptable value [ 42 ].…”