Interventions for the prevention of postoperative ear discharge after insertion of ventilation tubes (grommets) in children

Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

“…The cumulative proportion of treatment failure due to otorrhea was lower with OTO‐201 treatment at day 4 and continuing through day 29, with approximately a two‐thirds percentage reduction in otorrhea treatment failure risk for patients who received OTO‐201 (7%) relative to TT alone (19%) at day 15 (absolute risk reduction of 12%). This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 .…”

“…This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 . Future research into the comparison of caregiver burden and cost‐effectiveness of otic treatments should be considered.…”

“…[5][6][7] Furthermore, the observed otorrhea rate in the TT-alone group is similar to the range of 13% to 26% reported from a large meta-analysis and a literature review of the early postoperative period. 4,7 Future research into the comparison of caregiver burden and cost-effectiveness of otic treatments should be considered. Interestingly, a large number of children with baseline serous effusions had treatment failures (OTO-201 vs TT alone, 21% vs 43%; Figure 5), which supports the finding that bacterial pathogens reside in serous effusions and are underdetected by traditional bacterial culture methods; otherwise, one would not have expected a different response between OTO-201 and TT alone.…”

Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

“…The cumulative proportion of treatment failure due to otorrhea was lower with OTO‐201 treatment at day 4 and continuing through day 29, with approximately a two‐thirds percentage reduction in otorrhea treatment failure risk for patients who received OTO‐201 (7%) relative to TT alone (19%) at day 15 (absolute risk reduction of 12%). This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 .…”

“…This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 . Future research into the comparison of caregiver burden and cost‐effectiveness of otic treatments should be considered.…”

“…[5][6][7] Furthermore, the observed otorrhea rate in the TT-alone group is similar to the range of 13% to 26% reported from a large meta-analysis and a literature review of the early postoperative period. 4,7 Future research into the comparison of caregiver burden and cost-effectiveness of otic treatments should be considered. Interestingly, a large number of children with baseline serous effusions had treatment failures (OTO-201 vs TT alone, 21% vs 43%; Figure 5), which supports the finding that bacterial pathogens reside in serous effusions and are underdetected by traditional bacterial culture methods; otherwise, one would not have expected a different response between OTO-201 and TT alone.…”

Ventilation tube non-function due to blockage in children: the frequency, course and effect on hearing. A prospective cohort study

“…This could be viewed as a weakness; however, the Cochrane review by Syed et al ., published in 2013, concludes that ‘the use of an intervention to prevent postoperative ear discharge should be restricted to those at a high risk of this discharge’. 7 At the outset, the presented cohort was not seen as a ‘high risk’ group according to the authors.…”

Antibiotic prescribing practices in otolaryngology head and neck surgery in Australia and New Zealand: a survey of 137 specialists

“…A Cochrane systematic review and meta-analysis found that post-operative ototopical antibiotics were associated with a reduced incidence of post-operative otorrhea. However, the authors have recommended intervention only in patients with a high risk of ear discharge (15).…”

Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

“…The cumulative proportion of treatment failure due to otorrhea was lower with OTO‐201 treatment at day 4 and continuing through day 29, with approximately a two‐thirds percentage reduction in otorrhea treatment failure risk for patients who received OTO‐201 (7%) relative to TT alone (19%) at day 15 (absolute risk reduction of 12%). This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 .…”

“…This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 . Future research into the comparison of caregiver burden and cost‐effectiveness of otic treatments should be considered.…”

“…[5][6][7] Furthermore, the observed otorrhea rate in the TT-alone group is similar to the range of 13% to 26% reported from a large meta-analysis and a literature review of the early postoperative period. 4,7 Future research into the comparison of caregiver burden and cost-effectiveness of otic treatments should be considered. Interestingly, a large number of children with baseline serous effusions had treatment failures (OTO-201 vs TT alone, 21% vs 43%; Figure 5), which supports the finding that bacterial pathogens reside in serous effusions and are underdetected by traditional bacterial culture methods; otherwise, one would not have expected a different response between OTO-201 and TT alone.…”

Ventilation tube non-function due to blockage in children: the frequency, course and effect on hearing. A prospective cohort study

“…This could be viewed as a weakness; however, the Cochrane review by Syed et al ., published in 2013, concludes that ‘the use of an intervention to prevent postoperative ear discharge should be restricted to those at a high risk of this discharge’. 7 At the outset, the presented cohort was not seen as a ‘high risk’ group according to the authors.…”

Antibiotic prescribing practices in otolaryngology head and neck surgery in Australia and New Zealand: a survey of 137 specialists

“…A Cochrane systematic review and meta-analysis found that post-operative ototopical antibiotics were associated with a reduced incidence of post-operative otorrhea. However, the authors have recommended intervention only in patients with a high risk of ear discharge (15).…”

Phase 3 Trials of Thermosensitive Ciprofloxacin Gel for Middle Ear Effusion in Children with Tubes

“…The cumulative proportion of treatment failure due to otorrhea was lower with OTO‐201 treatment at day 4 and continuing through day 29, with approximately a two‐thirds percentage reduction in otorrhea treatment failure risk for patients who received OTO‐201 (7%) relative to TT alone (19%) at day 15 (absolute risk reduction of 12%). This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 .…”

“…This reduction in the rate of otorrhea is consistent with what has been reported for otic drops in pediatric patients undergoing TT surgery 5‐7 . Furthermore, the observed otorrhea rate in the TT‐alone group is similar to the range of 13% to 26% reported from a large meta‐analysis and a literature review of the early postoperative period 4,7 . Future research into the comparison of caregiver burden and cost‐effectiveness of otic treatments should be considered.…”

“…[5][6][7] Furthermore, the observed otorrhea rate in the TT-alone group is similar to the range of 13% to 26% reported from a large meta-analysis and a literature review of the early postoperative period. 4,7 Future research into the comparison of caregiver burden and cost-effectiveness of otic treatments should be considered. Interestingly, a large number of children with baseline serous effusions had treatment failures (OTO-201 vs TT alone, 21% vs 43%; Figure 5), which supports the finding that bacterial pathogens reside in serous effusions and are underdetected by traditional bacterial culture methods; otherwise, one would not have expected a different response between OTO-201 and TT alone.…”

Ventilation tube non-function due to blockage in children: the frequency, course and effect on hearing. A prospective cohort study

“…This could be viewed as a weakness; however, the Cochrane review by Syed et al ., published in 2013, concludes that ‘the use of an intervention to prevent postoperative ear discharge should be restricted to those at a high risk of this discharge’. 7 At the outset, the presented cohort was not seen as a ‘high risk’ group according to the authors.…”

Antibiotic prescribing practices in otolaryngology head and neck surgery in Australia and New Zealand: a survey of 137 specialists

“…A Cochrane systematic review and meta-analysis found that post-operative ototopical antibiotics were associated with a reduced incidence of post-operative otorrhea. However, the authors have recommended intervention only in patients with a high risk of ear discharge (15).…”