Interventions for preventing bone disease in kidney transplant recipients

Is Klotho F352V Polymorphism the Missing Piece of the Bone Loss Puzzle in Renal Transplant Recipients?

“…Present findings supported the results of the studies suggesting that active vitamin D supplementation may be more efficacious in preventing vertebral fractures in RT recipients compared to no-treatment, placebo or other forms of vitamin D with or without calcium supplementation [51,52,53]. Finding of a significant relation of 1,25D levels with bone loss only in the presence of F352V KL polymorphism suggested that KL polymorphism might be important in evaluation and management of bone loss in RT recipients.…”

Is Klotho F352V Polymorphism the Missing Piece of the Bone Loss Puzzle in Renal Transplant Recipients?

“…Present findings supported the results of the studies suggesting that active vitamin D supplementation may be more efficacious in preventing vertebral fractures in RT recipients compared to no-treatment, placebo or other forms of vitamin D with or without calcium supplementation [51,52,53]. Finding of a significant relation of 1,25D levels with bone loss only in the presence of F352V KL polymorphism suggested that KL polymorphism might be important in evaluation and management of bone loss in RT recipients.…”

What do Cochrane systematic reviews say about interventions for vitamin D supplementation?

“…The aim of the review 23 was to evaluate the use of interventions for preventing bone disease following kidney transplantation. Twenty-four RCTs (n = 1,299) were included.…”

Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management

“…When bisphosphonates were compared to alfacalcidol and calcitriol, bisphosphonates showed significant benefits in terms of BMD at the lumbar spine and the femoral neck. No significant effect of treatment with bisphosphonates for risk of low bone turnover and hypocalcemia was observed [71]. The use of bisphosphonates in patients living with kidney transplants did not result in a difference in ALP and PTH levels before and after treatment and had no adverse effects on eGFR [78].…”

Is Klotho F352V Polymorphism the Missing Piece of the Bone Loss Puzzle in Renal Transplant Recipients?

“…Present findings supported the results of the studies suggesting that active vitamin D supplementation may be more efficacious in preventing vertebral fractures in RT recipients compared to no-treatment, placebo or other forms of vitamin D with or without calcium supplementation [51,52,53]. Finding of a significant relation of 1,25D levels with bone loss only in the presence of F352V KL polymorphism suggested that KL polymorphism might be important in evaluation and management of bone loss in RT recipients.…”

What do Cochrane systematic reviews say about interventions for vitamin D supplementation?

“…The aim of the review 23 was to evaluate the use of interventions for preventing bone disease following kidney transplantation. Twenty-four RCTs (n = 1,299) were included.…”

Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management

“…When bisphosphonates were compared to alfacalcidol and calcitriol, bisphosphonates showed significant benefits in terms of BMD at the lumbar spine and the femoral neck. No significant effect of treatment with bisphosphonates for risk of low bone turnover and hypocalcemia was observed [71]. The use of bisphosphonates in patients living with kidney transplants did not result in a difference in ALP and PTH levels before and after treatment and had no adverse effects on eGFR [78].…”

Is Klotho F352V Polymorphism the Missing Piece of the Bone Loss Puzzle in Renal Transplant Recipients?

“…Present findings supported the results of the studies suggesting that active vitamin D supplementation may be more efficacious in preventing vertebral fractures in RT recipients compared to no-treatment, placebo or other forms of vitamin D with or without calcium supplementation [51,52,53]. Finding of a significant relation of 1,25D levels with bone loss only in the presence of F352V KL polymorphism suggested that KL polymorphism might be important in evaluation and management of bone loss in RT recipients.…”

What do Cochrane systematic reviews say about interventions for vitamin D supplementation?

“…The aim of the review 23 was to evaluate the use of interventions for preventing bone disease following kidney transplantation. Twenty-four RCTs (n = 1,299) were included.…”

Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management

“…When bisphosphonates were compared to alfacalcidol and calcitriol, bisphosphonates showed significant benefits in terms of BMD at the lumbar spine and the femoral neck. No significant effect of treatment with bisphosphonates for risk of low bone turnover and hypocalcemia was observed [71]. The use of bisphosphonates in patients living with kidney transplants did not result in a difference in ALP and PTH levels before and after treatment and had no adverse effects on eGFR [78].…”