Interventionist versus expectant care for severe pre-eclampsia before term

Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy

“…Increased energy and protein intake [ 28 ], altered dietary salt (2 reviews) [ 29 , 30 ] and exercise [ 31 ] during pregnancy were also excluded. Bed rest for hypertension [ 32 ], low dose dopamine for women with severe pre-eclampsia [ 33 ], plasma volume expansion for treatment of pre-eclampsia [ 34 ] or early delivery for severe pre-eclampsia before 34 weeks gestation [ 35 ] were also not found to be associated with any of the HDP-related maternal outcomes.…”

Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy

“…Increased energy and protein intake [ 28 ], altered dietary salt (2 reviews) [ 29 , 30 ] and exercise [ 31 ] during pregnancy were also excluded. Bed rest for hypertension [ 32 ], low dose dopamine for women with severe pre-eclampsia [ 33 ], plasma volume expansion for treatment of pre-eclampsia [ 34 ] or early delivery for severe pre-eclampsia before 34 weeks gestation [ 35 ] were also not found to be associated with any of the HDP-related maternal outcomes.…”

Assessment of the fullPIERS Risk Prediction Model in Women With Early-Onset Preeclampsia

“…In addition, observational studies have already shown that 50% of women with early-onset preeclampsia will deliver within 2 weeks and 25% within 4 weeks. 22 – 24 Therefore, it is possible that this model may not be useful for the prediction of maternal complications as iatrogenic delivery could be because of maternal or fetal indications or both. Another concern with the use of the PREP model is the inclusion of >14 variables, making it cumbersome compared with the fullPIERS model that requires only 6 variables.…”

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

“…A recent Cochrane review [10] has shown that expectant management reduced risk of fetal and neonatal complications without increase in maternal complications. Clinicians are reluctant to promote expectant management due to uncertainties around the scale of maternal risk.…”

Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy

“…Increased energy and protein intake [ 28 ], altered dietary salt (2 reviews) [ 29 , 30 ] and exercise [ 31 ] during pregnancy were also excluded. Bed rest for hypertension [ 32 ], low dose dopamine for women with severe pre-eclampsia [ 33 ], plasma volume expansion for treatment of pre-eclampsia [ 34 ] or early delivery for severe pre-eclampsia before 34 weeks gestation [ 35 ] were also not found to be associated with any of the HDP-related maternal outcomes.…”

Assessment of the fullPIERS Risk Prediction Model in Women With Early-Onset Preeclampsia

“…In addition, observational studies have already shown that 50% of women with early-onset preeclampsia will deliver within 2 weeks and 25% within 4 weeks. 22 – 24 Therefore, it is possible that this model may not be useful for the prediction of maternal complications as iatrogenic delivery could be because of maternal or fetal indications or both. Another concern with the use of the PREP model is the inclusion of >14 variables, making it cumbersome compared with the fullPIERS model that requires only 6 variables.…”

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

“…A recent Cochrane review [10] has shown that expectant management reduced risk of fetal and neonatal complications without increase in maternal complications. Clinicians are reluctant to promote expectant management due to uncertainties around the scale of maternal risk.…”

Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy

“…Increased energy and protein intake [ 28 ], altered dietary salt (2 reviews) [ 29 , 30 ] and exercise [ 31 ] during pregnancy were also excluded. Bed rest for hypertension [ 32 ], low dose dopamine for women with severe pre-eclampsia [ 33 ], plasma volume expansion for treatment of pre-eclampsia [ 34 ] or early delivery for severe pre-eclampsia before 34 weeks gestation [ 35 ] were also not found to be associated with any of the HDP-related maternal outcomes.…”

Assessment of the fullPIERS Risk Prediction Model in Women With Early-Onset Preeclampsia

“…In addition, observational studies have already shown that 50% of women with early-onset preeclampsia will deliver within 2 weeks and 25% within 4 weeks. 22 – 24 Therefore, it is possible that this model may not be useful for the prediction of maternal complications as iatrogenic delivery could be because of maternal or fetal indications or both. Another concern with the use of the PREP model is the inclusion of >14 variables, making it cumbersome compared with the fullPIERS model that requires only 6 variables.…”

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

“…A recent Cochrane review [10] has shown that expectant management reduced risk of fetal and neonatal complications without increase in maternal complications. Clinicians are reluctant to promote expectant management due to uncertainties around the scale of maternal risk.…”