Intervention-induced Enhancement in Intrinsic Brain Activity in Healthy Older Adults

Yin, Shufei; Zhu, Xinyi; Li, Rui; Niu, Yanan; Wang, Baoxi; Zheng, Zhili; Huang, Xin; Li, Juan

doi:10.1016/j.brs.2015.01.320

Cited by 7 publications

(18 citation statements)

References 29 publications

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“…Heinzel et al (2016) reported a decreased MFG response that was associated with improvement on WM and transfer EF tasks following a 12week Sternberg training. Finally, Yin et al (2014) reported increased MFG activity that positively correlated with psychomotor speed and set-shifting following a 6-week multimodal training. Evidence thus suggests that neural effects may be prominent in the MFG following CT and warrant future investigation.…”

Section: Discussionmentioning

confidence: 92%

Functional brain changes associated with cognitive training in healthy older adults: A preliminary ALE meta-analysis

Duda

Sweet

2019

Brain Imaging and Behavior

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Accumulating evidence suggests that cognitive training (CT) programs may provide healthy older adults (OAs) with cognitive benefits that are accompanied by alterations in neural activity. The current review offers the first quantitative synthesis of the available literature on the neural effects of CT in healthy aging. It was hypothesized that OAs would evidence increased and decreased neural activations across various challenging CTs, and that these effects would be observed as significantly altered clusters within regions of the frontoparietal network (FPN). Online databases and reference lists were searched to identify peerreviewed publications that reported assessment of neural changes associated with CT programs in healthy OAs. Among the 2097 candidate studies identified, 14 studies with a total of 238 participants met inclusionary criteria. GingerALE software was used to quantify neural effects in a whole-brain analysis. The activation likelihood estimation technique revealed significant increases in activation following CT in the left hemisphere middle frontal gyrus, precentral gyrus, and posterior parietal cortex, extending to the superior occipital gyrus. Two clusters of diminished neural activity following CT were identified within the right hemisphere middle frontal gyrus and supramarginal gyrus, extending to the superior temporal gyrus. These results provide preliminary evidence of common neural effects of different CT interventions within regions of the FPN. Findings may inform future investigations of neuroplasticity across the lifespan, including clinical applications of CT, such as assessing treatment outcomes.

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Section: Discussionmentioning

confidence: 92%

Functional brain changes associated with cognitive training in healthy older adults: A preliminary ALE meta-analysis

Duda

Sweet

2019

Brain Imaging and Behavior

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“…One training study has shown that increases in ALFF in the superior frontal gyrus and decreases in ALFF in the default mode network correlated with performance improvement after language training in young adults (Deng, Chandrasekaran, Wang, & Wong, ). Another study found that ALFF in areas of the middle frontal gyrus correlated with behavioral change in older adults (Yin et al, ). Whether the negative relationship between hippocampal fALFF and plasticity is a deleterious effect of high fALFF, or if low fALFF facilitates plasticity through an unknown pathway is not clear.…”

Section: Discussionmentioning

confidence: 99%

Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adults

Bråthen

Lange

Rohani

et al. 2018

Human Brain Mapping

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Episodic memory can be trained in both early and late adulthood, but there is considerable variation in cognitive improvement across individuals. Which brain characteristics make some individuals benefit more than others? We used a multimodal approach to investigate whether volumetric magnetic resonance imaging (MRI) and resting-state functional MRI characteristics of the cortex and hippocampus, brain regions involved in episodic-memory function, were predictive of cognitive improvement after memory training. We hypothesized that these brain characteristics would differentially predict memory improvement in young and older adults, given the vulnerability of cortical regions as well as the hippocampus to healthy aging. Following structural and resting-state activity magnetic resonance scans, 50 young and 76 older participants completed 10 weeks of strategic episodic-memory training. Both age groups improved their memory performance, but the young adults more so than the older. Vertex-wise analyses of cortical volume showed no significant relation to memory benefit. When analyzing the two age groups separately, hippocampal volume was predictive of memory improvement in the group of older participants only. In this age group, the lower resting-state activity of the hippocampus was also predictive of memory improvement. Both volumetric and resting-state characteristics of the hippocampus explained unique variance of the improvement in the older participants suggesting that a multimodal imaging approach is valuable for the understanding of mechanisms underlying memory plasticity in aging.

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“…Therefore, older adults may need more daily companionship from their family members, relatives, and friends, and geriatric care services, such as home care are urgently needed [33,35]. For another thing, priority should be given to raising public awareness of cognitive dysfunction and increasing medical support resources for early prevention, evaluation, intervention, and medical treatment of mental illness and poor health status in the elderly [36,37].…”

Section: Discussionmentioning

confidence: 99%

Potential associated factors of functional disability in Chinese older inpatients: a multicenter cross-sectional study

et al. 2020

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Background: There is still controversy about the relationship between aging and changes in functional ability. This study aims to describe the level of basic activities of daily living (ADL) and higher-level instrumental activities of daily living (IADL) in different age groups and explore the factors associated with functional disability in Chinese older inpatients. Methods: This cross-sectional study surveyed 9996 older inpatients aged 65 years and older from six tertiary hospitals in China from October 2018 to February 2019. The levels of ADL and IADL were measured by scores of the Barthel index and Instrumental Activities of Daily Living Scale. A mixed-effect generalized linear model was used to examine the association between functional disability and covariates. Results: The average ADL score was 89.51 ± 19.29 and the mean IADL score 6.76 ± 2.01 for all participants. There was a trend of decreasing scores along with aging, and significant differences between age groups were also observed (P < 0.001). The most affected ADL and IADL was stair climbing and shopping, respectively. Sociodemographic characteristics (such as age), physical health variables (frailty, emaciation, hearing dysfunction, urinary dysfunction, defecation dysfunction, falling accidents in the past 12 months), and mental health variables (cognitive dysfunction, depression) were associated with functional disability. Patients from the emergency department or transferred from other hospitals and former alcohol drinkers are at risk of ADL disability. Former smoking is a risk factor for IADL disability, whereas current drinking, higher-level education, and residing in a building without elevators were likely to maintain a better IADL performance.

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Intervention-induced Enhancement in Intrinsic Brain Activity in Healthy Older Adults

Cited by 7 publications

References 29 publications

Functional brain changes associated with cognitive training in healthy older adults: A preliminary ALE meta-analysis

Functional brain changes associated with cognitive training in healthy older adults: A preliminary ALE meta-analysis

Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adults

Potential associated factors of functional disability in Chinese older inpatients: a multicenter cross-sectional study

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