Interval breast cancer is associated with interferon immune response

Ugalde-Morales, Emilio; Graßmann, Felix; Humphreys, Keith; Li, Jingmei; Eriksson, Mikael; Tobin, Nicholas P.; Lindström, Linda S.; Vallon‐Christersson, Johan; Borg, Åke; Hall, Per; Czene, Kamila

doi:10.1016/j.ejca.2021.12.003

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Tumour characteristics such as oestrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, grade and lymph node involvement were retrieved from medical records or from the Swedish National Cancer Registry. Mode of detection was defined by the timing between the last mammographic screening and time of diagnosis [ 18 , 19 ]. Briefly, women diagnosed between two scheduled screening intervals without a detectable tumour in the previous screening were deemed to have interval breast cancer (IC).…”

Section: Methodsmentioning

confidence: 99%

The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk

Grassmann,

Mälarstig,

Dahl

et al. 2023

Br J Cancer

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Objective Current breast cancer risk prediction scores and algorithms can potentially be further improved by including molecular markers. To this end, we studied the association of circulating plasma proteins using Proximity Extension Assay (PEA) with incident breast cancer risk. Subjects In this study, we included 1577 women participating in the prospective KARMA mammographic screening cohort. Results In a targeted panel of 164 proteins, we found 8 candidates nominally significantly associated with short-term breast cancer risk (P < 0.05). Similarly, in an exploratory panel consisting of 2204 proteins, 115 were found nominally significantly associated (P < 0.05). However, none of the identified protein levels remained significant after adjustment for multiple testing. This lack of statistically significant findings was not due to limited power, but attributable to the small effect sizes observed even for nominally significant proteins. Similarly, adding plasma protein levels to established risk factors did not improve breast cancer risk prediction accuracy. Conclusions Our results indicate that the levels of the studied plasma proteins captured by the PEA method are unlikely to offer additional benefits for risk prediction of short-term overall breast cancer risk but could provide interesting insights into the biological basis of breast cancer in the future.

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Section: Methodsmentioning

confidence: 99%

The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk

Grassmann,

Mälarstig,

Dahl

et al. 2023

Br J Cancer

Self Cite

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“…The presence of specific microorganisms is thought to be associated with certain immune responses 14 . Additionally, directly modulating the host immune response can be a powerful way to disrupt the progression of cancer 15 . However, a variety of immune cells play major roles in the immune response, and the immune cells that play key roles in the antitumour immune response include macrophages (Møs) and natural killer (NK) cells 16 , in addition to CD8 + cytotoxic T cells (CTLs) and CD4 + T cells, which can be divided into four major lineages, T-helper 1 (Th1), T-helper 2 (Th2), T-helper 17 (Th17) and T-regulatory cells (Tregs) 17 .…”

Section: Introductionmentioning

confidence: 99%

Aspirin prevents colorectal cancer by regulating the abundance of Enterococcus cecorum and TIGIT+Treg cells

Yang,

Yan,

Wang

et al. 2024

Sci Rep

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Although aspirin can reduce the incidence of colorectal cancer (CRC), there is still uncertainty about its significance as a treatment for CRC, and the mechanism of aspirin in CRC is not well understood. In this study, we used aspirin to prevent AOM/DSS-induced CRC in mice, and the anti-CRC efficacy of aspirin was assessed using haematoxylin and eosin (H&E) staining and by determining the mouse survival rate and tumour size. 16S rDNA sequencing, flow cytometry (FCM), and Western blotting were also conducted to investigate the changes in the gut microbiota, tumour immune microenvironment, and apoptotic proteins, respectively. The results demonstrated that aspirin significantly exerted anti-CRC effects in mice. According to 16S rDNA sequencing, aspirin regulated the composition of the gut microbiota and dramatically reduced the abundance of Enterococcus cecorum. FCM demonstrated that there were more CD155 tumour cells and CD4 + CD25 + Treg cells showed increased TIGIT levels. Moreover, increased TIGIT expression on Treg cells is associated with reduced Treg cell functionality. Importantly, the inhibition of Treg cells is accompanied by the promotion of CD19 + GL-7 + B cells, CD8 + T cells, CD4 + CCR4 + Th2 cells, and CD4 + CCR6 + Th17 cells. Overall, aspirin prevents colorectal cancer by regulating the abundance of Enterococcus cecorum and TIGIT + Treg cells.

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