Interstitial pericytes decrease in aged mouse kidneys

Stefanska, Ania; Eng, Diana G.; Kaverina, Natalya V.; Duffield, Jeremy S.; Pippin, Jeffrey W.; Rabinovitch, Peter S.; Shankland, Stuart J.

doi:10.18632/aging.100756

Cited by 30 publications

(28 citation statements)

References 72 publications

(89 reference statements)

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“…To the best knowledge of the authors, this is the first study that demonstrates a correlation between pericyte number and steatosis induced by periodontitis. A reduction in pericytes in the kidney has been shown to be a critical step in the development of fibrosis 32 . It has been suggested that NG2 positive cells may act as repository cells with great potential for differentiation 14 .…”

Section: Discussionmentioning

confidence: 99%

“…A reduction in pericytes in the kidney has been shown to be a critical step in the development of fibrosis. 32 It has been suggested that NG2 positive cells may act as repository cells with great potential for differentiation. 14 Similarly, findings from the current study suggest that reduction of hepatic pericytes is associated with microvesicular steatosis.…”

Section: Discussionmentioning

confidence: 99%

Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats

Vasconcelos

Silva

Pinto

et al. 2017

Journal of Periodontology

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“…p16INK4a and SA-b-galactosidase are markers for senescent cells and increased in aged animals and postinjury. G2/M arrest seen in scarred kidneys in response to injury 92 Increased numbers of senescent renal cells correlate with increased injury and reduced transplant function 145,146 Vascular changes Aged mice aortas have increased G2/M-phase cell cycle arrest in vitro 198 Reduced renal capillary density in aged mice 124 and in response to severe IRI 114 Increased renal vascular tone and vascular stiffening with age. 199 Loss of efficacy of vasodilators 200…”

Section: Age Accumulates With Age 141mentioning

confidence: 99%

Renal Aging: Causes and Consequences

O'Sullivan

Hughes

Ferenbach

2016

JASN

258

244

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Individuals age >65 years old are the fastest expanding population demographic throughout the developed world. Consequently, more aged patients than before are receiving diagnoses of impaired renal function and nephrosclerosis-age-associated histologic changes in the kidneys. Recent studies have shown that the aged kidney undergoes a range of structural changes and has altered transcriptomic, hemodynamic, and physiologic behavior at rest and in response to renal insults. These changes impair the ability of the kidney to withstand and recover from injury, contributing to the high susceptibility of the aged population to AKI and their increased propensity to develop subsequent progressive CKD. In this review, we examine these features of the aged kidney and explore the various validated and putative pathways contributing to the changes observed with aging in both experimental animal models and humans. We also discuss the potential for additional study to increase understanding of the aged kidney and lead to novel therapeutic strategies.

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“…This proposed mechanism may also keep pericytes from detaching and migrating into the interstitium away from a growing vessel. While more studies will be necessary to better understand the existence of these and potentially other pericyte‐retention mechanisms, pericyte loss by detachment and interstitial migration has been described for numerous disease conditions . It will therefore be important to further elucidate this phenomenon in healthy and pathological conditions.…”

Section: Pericyte Involvement In Angiogenic Sproutingmentioning

confidence: 99%

“…While more studies will be necessary to better understand the existence of these and potentially other pericyte-retention mechanisms, pericyte loss by detachment and interstitial migration has been described for numerous disease conditions. 24,25,94,[115][116][117][118][119][120][121][122][123] It will therefore be (Figure 2 and Movie S1), it must adhere to and migrate along a permissive substrate, which might be the endothelial cell surface itself. Alternatively, pericytes may engage an intermediate form of the vBM that is being jointly produced by the endothelium and associated pericytes.…”

Section: Peric Y Te Involvement In Ang Iog Enic S Proutingmentioning

confidence: 99%

The pericyte microenvironment during vascular development

et al. 2019

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Vascular pericytes provide critical contributions to the formation and integrity of the blood vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis by promoting endothelial cell junctions and depositing extracellular matrix (ECM) components within the vascular basement membrane, among other vital functions. As their importance in sustaining microvessel health within various tissues and organs continues to emerge, so does their role in a number of pathological conditions including cancer, diabetic retinopathy, and neurological disorders. Here, we review vascular pericyte contributions to the development and remodeling of the microcirculation, with a focus on the local microenvironment during these processes. We discuss observations of their earliest involvement in vascular development and essential cues for their recruitment to the remodeling endothelium. Pericyte involvement in the angiogenic sprouting context is also considered with specific attention to crosstalk with endothelial cells such as through signaling regulation and ECM deposition. We also address specific aspects of the collective cell migration and dynamic interactions between pericytes and endothelial cells during angiogenic sprouting. Lastly, we discuss pericyte contributions to mechanisms underlying the transition from active vessel remodeling to the maturation and quiescence phase of vascular development.

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Interstitial pericytes decrease in aged mouse kidneys

Cited by 30 publications

References 72 publications

Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats

Renal Aging: Causes and Consequences

The pericyte microenvironment during vascular development

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