2015
DOI: 10.18632/aging.100756
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Abstract: With increasing age, the kidney undergoes characteristic changes in the glomerular and tubulo-interstitial compartments, which are ultimately accompanied by reduced kidney function. Studies have shown age-related loss of peritubular vessels. Normal peritubular vessel tone, function and survival depend on neighboring pericytes. Pericyte detachment leads to vascular damage, which can be accompanied by their differentiation to fibroblasts and myofibroblasts, a state that favors matrix production. To better unders… Show more

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Cited by 30 publications
(28 citation statements)
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References 72 publications
(28 reference statements)
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“…To the best knowledge of the authors, this is the first study that demonstrates a correlation between pericyte number and steatosis induced by periodontitis. A reduction in pericytes in the kidney has been shown to be a critical step in the development of fibrosis 32 . It has been suggested that NG2 positive cells may act as repository cells with great potential for differentiation 14 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…To the best knowledge of the authors, this is the first study that demonstrates a correlation between pericyte number and steatosis induced by periodontitis. A reduction in pericytes in the kidney has been shown to be a critical step in the development of fibrosis 32 . It has been suggested that NG2 positive cells may act as repository cells with great potential for differentiation 14 .…”
Section: Discussionmentioning
confidence: 99%
“…A reduction in pericytes in the kidney has been shown to be a critical step in the development of fibrosis. 32 It has been suggested that NG2 positive cells may act as repository cells with great potential for differentiation. 14 Similarly, findings from the current study suggest that reduction of hepatic pericytes is associated with microvesicular steatosis.…”
Section: Discussionmentioning
confidence: 99%
“…p16INK4a and SA-b-galactosidase are markers for senescent cells and increased in aged animals and postinjury. G2/M arrest seen in scarred kidneys in response to injury 92 Increased numbers of senescent renal cells correlate with increased injury and reduced transplant function 145,146 Vascular changes Aged mice aortas have increased G2/M-phase cell cycle arrest in vitro 198 Reduced renal capillary density in aged mice 124 and in response to severe IRI 114 Increased renal vascular tone and vascular stiffening with age. 199 Loss of efficacy of vasodilators 200…”
Section: Age Accumulates With Age 141mentioning
confidence: 99%
“…This proposed mechanism may also keep pericytes from detaching and migrating into the interstitium away from a growing vessel. While more studies will be necessary to better understand the existence of these and potentially other pericyte‐retention mechanisms, pericyte loss by detachment and interstitial migration has been described for numerous disease conditions . It will therefore be important to further elucidate this phenomenon in healthy and pathological conditions.…”
Section: Pericyte Involvement In Angiogenic Sproutingmentioning
confidence: 99%
“…While more studies will be necessary to better understand the existence of these and potentially other pericyte-retention mechanisms, pericyte loss by detachment and interstitial migration has been described for numerous disease conditions. 24,25,94,[115][116][117][118][119][120][121][122][123] It will therefore be (Figure 2 and Movie S1), it must adhere to and migrate along a permissive substrate, which might be the endothelial cell surface itself. Alternatively, pericytes may engage an intermediate form of the vBM that is being jointly produced by the endothelium and associated pericytes.…”
Section: Peric Y Te Involvement In Ang Iog Enic S Proutingmentioning
confidence: 99%