Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control

Dempsey, Paddy C.; Blankenship, Jennifer M.; Larsen, Robyn N.; Sacre, Julian W.; Sethi, Parneet; Straznicky, Nora E.; Cohen, Neale; Cerin, Ester; Lambert, Gavin W.; Owen, Neville; Kingwell, Bronwyn A.; Dunstan, David W.

doi:10.1007/s00125-016-4169-z

Cited by 94 publications

(151 citation statements)

References 36 publications

Supporting

Mentioning

138

Contrasting

Order By: Relevance

“…When considering T2D patients, introducing light walking breaks reduced 7 h glucose, insulin, and C-peptide, compared with prolonged sitting (Dempsey et al, 2016b). The same authors verified that the glycemic improvements that arise from breaking up sedentary time persist until the next morning, indicating that there may be medium to long term benefits in T2D patients (Dempsey et al, 2016a). Even though these experimental findings are of great importance (because they allow establishing causal relationships between BST and metabolic outcomes) the laboratorial settings and protocols in which they are performed, do not mimic real-life conditions and limit their ecological transfer.…”

Section: Discussionmentioning

confidence: 89%

“…When considering experimental evidence (Dunstan et al, 2012; Howard et al, 2013; Latouche et al, 2013; Larsen et al, 2014; Bailey and Locke, 2015; Dempsey et al, 2016a,b), breaking up prolonged sedentary time with light ambulation is still an effective strategy for improving glucose regulation, which further clarifies the need to expand current diabetes-related PA guidelines, by introducing regular breaks in prolonged sedentary time (Dempsey et al, 2016c). Dunstan et al (2012) found that breaking up sedentary time with LIPA bouts reduced 5 h glucose iAUC by 24% and 5 h insulin iAUC by 23%.…”

Section: Discussionmentioning

confidence: 99%

“…Mounting evidence suggests that breaking up prolonged sedentary time by light ambulation is an effective strategy for improving postprandial glucose regulation (Dunstan et al, 2012; Howard et al, 2013; Latouche et al, 2013; Larsen et al, 2014; Bailey and Locke, 2015; Dempsey et al, 2016a,b), and a recent meta-analysis revealed that breaks of at least light intensity in sedentary periods may have a positive effect on glycemia, independently of total sedentary time (Chastin et al, 2015). Dunstan et al (2012) found that introducing light walking breaks every 20 min (2-min breaks) reduced 5 h glucose incremental area under the curve (iAUC) by 24% and 5 h insulin iAUC by 23%.…”

Section: Introductionmentioning

confidence: 99%

“…Introducing light walking breaks reduced T2D patients' 7 h glucose, insulin, and C-peptide iAUC, compared with prolonged sitting (Dempsey et al, 2016b). Interestingly, 22 h hyperglycemia was also reduced and glycemic improvements persisted nocturnally, until the following morning (Dempsey et al, 2016a). …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

et al. 2017

View full text Add to dashboard Cite

Background: Sedentary behavior has been considered an independent risk factor for type-2 diabetes (T2D), with a negative impact on several physiological outcomes, whereas breaks in sedentary time (BST) have been proposed as a viable solution to mitigate some of these effects. However, little is known about the independent associations of sedentary pursuits, physical activity, and cardiorespiratory fitness (CRF) variables with glycemic control. We investigated the independent associations of total sedentary time, BST, moderate-to-vigorous physical activity (MVPA), and CRF with glycemic outcomes in patients with T2D.Methods: Total sedentary time, BST, and MVPA were assessed in 66 participants (29 women) with T2D, using accelerometry. Glucose and insulin were measured during a mixed meal tolerance test, with the respective calculations of HOMA-IR and Matsuda index. Glycated hemoglobin (HbA1c) was also analyzed. CRF was measured in a maximal treadmill test with breath-by-breath gases analysis. Multiple regressions were used for data analysis.Results: Regardless of CRF, total sedentary time was positively associated with HbA1c (β = 0.25, p = 0.044). Adjusting for MVPA, total sedentary time was related to fasting glucose (β = 0.32, p = 0.037). No associations between total sedentary time and the remaining glycemic outcomes, after adjusting for MVPA. BST had favorable associations with HOMA-IR (β = −0.28, p = 0.047) and fasting glucose (β = −0.25, p = 0.046), when adjusted for MVPA, and with HOMA-IR (β = −0.25, p = 0.036), Matsuda index (β = 0.26, p = 0.036), and fasting glucose (β = −0.22, p = 0.038), following adjustment for CRF. When adjusting for total sedentary time, only CRF yielded favorable associations with HOMA-IR (β = −0.29, p = 0.039), fasting glucose (β = −0.32, p = 0.012), and glucose at 120-min (β = −0.26, p = 0.035), and no associations were found for MVPA with none of the metabolic outcomes.Conclusion: The results from this study suggest that sedentary time and patterns are relevant for the glycemic control in patients with T2D. Still, MVPA and CRF counteracted most of the associations for total sedentary time but not for the BST. MVPA was not associated with metabolic outcomes, and CRF lost some of the associations with glycemic indicators when adjusted for total sedentary time. Future interventions aiming to control/improve T2D must consider reducing and breaking up sedentary time as a viable strategy to improve glycemic control.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In addition, Healy et al (11) reported that increased breaks in SED-time were beneficially associated with metabolic profile, independent of MVPA and also total SED-time. More recent studies confirmed the benefits from interrupting prolonged sitting with brief bouts of light-intensity PA (LPA) in patients with type 2 diabetes (12)(13)(14).…”

mentioning

confidence: 93%

Effect of a Behavioral Intervention Strategy for Adoption and Maintenance of a Physically Active Lifestyle: The Italian Diabetes and Exercise Study 2 (IDES_2)

et al. 2017

View full text Add to dashboard Cite

OBJECTIVEAdherence to physical activity (PA) recommendations is hampered by the lack of effective strategies to promote behavior change. The Italian Diabetes and Exercise Study 2 (IDES_2) is a randomized controlled trial evaluating a novel behavioral intervention strategy for increasing PA and decreasing sedentary time (SED-time) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODSThe study randomized 300 physically inactive and sedentary patients with type 2 diabetes 1:1 to receive theoretical and practical counseling once yearly for 3 years (intervention group [INT]) or standard care (control group [CON]). Here, we report the 4-month effects on objectively (accelerometer) measured daily light-intensity PA (LPA), moderate-to-vigorous-intensity PA (MVPA), and SED-time, and cardiovascular risk factors. RESULTSLPA and MVPA both increased, and SED-time decreased in both groups, although changes were significantly more marked in INT participants (approximately twofold for LPA and SED-time and approximately sixfold for MVPA). A significant reduction in HbA 1c was observed only in INT subjects. An increase in LPA >0.92 h · day 21 and in MVPA >7.33 min · day 21 and a decrease in SED-time >1.05 h · day 21 were associated with an average decrease in HbA 1c of ∼1% and also with significant improvements in fasting glucose, body weight, waist circumference, and hs-CRP. Changes in PA and SED-time were independent predictors of improvements in HbA 1c . CONCLUSIONSThis behavioral intervention is effective in the short term for increasing LPA and MVPA and reducing SED-time. Significant improvements in cardiometabolic risk profiles were observed in subjects experiencing the most pronounced changes in PA and SED-time, even if below the recommended level.

show abstract

Non‐Surgical Management of Obesity

Hanson¹,

Barber²

2022

Handbook of Metabolic and Bariatric Surgery

View full text Add to dashboard Cite

Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control

Abstract: anzctr.org.au ACTRN12613000576729 FUNDING: : This research was supported by a National Health and Medical Research Council (NHMRC) project grant (no. 1081734) and the Victorian Government Operational Infrastructure Support scheme.

Cited by 94 publications

References 36 publications

Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

Effect of a Behavioral Intervention Strategy for Adoption and Maintenance of a Physically Active Lifestyle: The Italian Diabetes and Exercise Study 2 (IDES_2)

Non‐Surgical Management of Obesity

Contact Info

Product

Resources

About