Interrelationships of Molybdenum and Copper in the Diet of the Guinea Pig

Arthur, D.

doi:10.1093/jn/87.1.69

Cited by 28 publications

(16 citation statements)

References 15 publications

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“…Sorghum contains high levels of molybdenum as compared with other cereals (Deosthale et al 1977). High molybdenum intake is known to cause secondary deficiency of copper, an essential element for bone development (Arthur 1965). It is also observed that copper deficiency along with high fluoride intake is associated with high prevalence of genu valgum (Krishnamachari and Krishnaswamy 1973;Krishnamachari 1976Krishnamachari , 1986.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of fluorosis and identification of fluoride endemic areas in Manur block of Tirunelveli District, Tamil Nadu, South India

2012

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Prevalence of fluorosis is mainly due to the consumption of more fluoride through drinking water. It is necessary to identify the fluoride endemic areas to adopt remedial measures for the people under the risk of fluorosis. The objectives of this study were to identify the exact location of fluoride endemic areas in Manur block of Tirunelveli District and to estimate fluoride exposure level through drinking water for different age groups. Identification of fluoride endemic areas was performed through Isopleth and Google earth mapping techniques. Fluoride level in drinking water samples was estimated by fluoride ion selective electrode method. A systematic clinical survey conducted in 19 villages of Manur block revealed the rate of prevalence of fluorosis. From this study, it has been found that Alavanthankulam, Melapilliyarkulam, Keezhapilliyarkulam, Nadupilliyarkulam, Keezhathenkalam and Papankulam are the fluoride endemic villages, where the fluoride level in drinking water is above 1 mg/l. Consumption of maximum fluoride exposure levels of 0.30 mg/ kg/day for infants, 0.27 mg/kg/day for children and 0.15 mg/kg/day for adults were found among the respective age group people residing in high fluoride endemic area. As compared with adequate intake level of fluoride of 0.01 mg/kg/day for infants and 0.05 mg/kg/day for other age groups, the health risk due to excess fluoride intake to the people of Alavanthankulam and nearby areas has become evident. Hence the people of these areas are advised to consume drinking water with optimal fluoride to avoid further fluorosis risks.

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Section: Discussionmentioning

confidence: 99%

Prevalence of fluorosis and identification of fluoride endemic areas in Manur block of Tirunelveli District, Tamil Nadu, South India

2012

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“…The LOAEL was 75 mg molybdenum/kg bw/day based on loss of copper, growth depression and achromotrichia. Guinea pigs appear to be a less sensitive species to large doses of molybdenum (Arthur, 1965).…”

Section: Animal Studiesmentioning

confidence: 98%

Potassium molybdate as a source of molybdenum added for nutritional purposes to food supplements

2009

EFS2

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“…Mature rats are said to be more resistant to molybdenum toxicity5,6). However, in order to fully explain these contradictory results, further investigations are required to clarify (i) the site(s) of action of molybdenum toxicity in the animal body in relation to various toxicity symptoms such as excessive mortality, growth depression, anemia, diarrhea, alopecia, achromatrichia and emaciation6, 8,9), and (ii) dietary factors that influence molybdenum metabolism including sulfate, sulfide, and other unidentified factors8) which are suggested to increase the occurrence of molybdenum toxicity.…”

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confidence: 99%