Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease

Rohani, Morteza; Jogestrand, Tomas; Ekberg, Margareta; Linden, Jan van der; Källner, Göran; Jussila, Risto; Agewall, Stefan

doi:10.1016/j.atherosclerosis.2004.10.012

Cited by 112 publications

(87 citation statements)

References 25 publications

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“…Many clinical studies have now confirmed that the detection of asymptomatic carotid atherosclerosis is an early marker of ischemic heart disease and increased cardiovascular risk [8,9]. Moreover, it has been shown that the presence of carotid atherosclerotic disease is a valid marker of coronary atherosclerosis in subjects with symptomatic aortic stenosis [10].…”

Section: Discussionmentioning

confidence: 98%

Association between asymptomatic carotid atherosclerosis and degenerative aortic stenosis

et al. 2012

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a b s t r a c tObjective: Degenerative aortic stenosis shows similarities with atherosclerosis. To confirm the hypothesis that aortic stenosis is an "atherosclerosis-like" disease, we investigated the association between degenerative aortic stenosis and atherosclerosis of carotid arteries. Methods: We studied 270 consecutive patients, 135 with degenerative aortic stenosis (trans-aortic peak velocity ! 2 m/sec) and other 135 subjects without aortic valve disease. All patients underwent echocardiography and ultrasound scan of the supra-aortic trunks to assess the presence of plaque and/or intima-media thickening (IMT). Results: Atherosclerosis of carotid arteries (IMT and plaque) was significantly more frequent in patients with aortic stenosis than in controls (95.5% vs. 66.6%, p < 0.0001). The same result was confirmed as concerns carotid plaques (69.6% vs. 42.2%, p < 0.0001). In addition, there was a significant association between aortic stenosis and degenerative carotid plaque (OR ¼ 3.13; 95% C.I. ¼ 1.90e5.17). Thus the presence of a linear correlation between the trans-aortic peak velocity of the cases and the thickness of the plaques and IMT was evaluated by calculating the coefficient of correlation (R ¼ 0.15 for plaque and R ¼ 0.53 for IMT). Conclusions: The presence of carotid atherosclerosis is associated with degenerative aortic stenosis and the severity of aortic stenosis corresponds to an increase of the thickness of plaque and IMT. This relationship is quite new. Our result strengthens the pathogenetic hypothesis "atherosclerosis-like" of degenerative aortic stenosis and suggest the ultrasound scan as a non invasive method for risk stratification in patient with aortic stenosis, with therapeutic implications especially for higher risk subgroups.

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Section: Discussionmentioning

confidence: 98%

Association between asymptomatic carotid atherosclerosis and degenerative aortic stenosis

et al. 2012

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“…As atherosclerosis is a systemic disease, its presence in one vascular territory increases its existence and associated risk of clinical adverse events in other vascular territories (2). Current risk stratification guidelines are based on the major traditional risk factors for cardiovascular disease which have suboptimal predictive value (3).…”

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confidence: 99%

Agreement between methods of measurement of mean aortic wall thickness by MRI

Rosero

Peshock

Khera

et al. 2009

Magnetic Resonance Imaging

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Purpose: To assess the agreement between three methods of calculation of mean aortic wall thickness (MAWT) using magnetic resonance imaging (MRI). Materials and Methods:High-resolution MRI of the infrarenal abdominal aorta was performed on 70 subjects with a history of coronary artery disease who were part of a multiethnic population-based sample. MAWT was calculated as the mean distance between the adventitial and luminal aortic boundaries using three different methods: average distance at four standard positions (AWT-4P), average distance at 100 automated positions (AWT-100P), and using a mathematical computation derived from the total vessel and luminal areas (AWT-VA). Bland-Altman plots and Passing-Bablok regression analyses were used to assess agreement between methods. Results:Bland-Altman analyses demonstrated a positive bias of 3.02 Ϯ 7.31% between the AWT-VA and the AWT-4P methods, and of 1.76 Ϯ 6.82% between the AWT-100P and the AWT-4P methods. Passing-Bablok regression analyses demonstrated constant bias between the AWT-4P method and the other two methods. Proportional bias was, however, not evident among the three methods. Conclusion:MRI methods of measurement of MAWT using a limited number of positions of the aortic wall systematically underestimate the MAWT value compared with the method that calculates MAWT from the vessel areas.

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“…Carotid Intimal Medial Thickness can be a useful marker of atherosclerosis and has been shown to correlate with CV risk factors and predict stroke and myocardial infarction in the general population [17]. Results of CIMT in HIV-infected women have been mixed with a few studies finding no significant difference between HIV-infected females and HIVuninfected females [15,18].…”

Section: Carotid Intimal Media Thickness (Cimt)mentioning

confidence: 99%

Review of Cardiovascular Disease in HIV-Infected Women

Adekunle¹

2016

J AIDS Clin Res

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Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease

Cited by 112 publications

References 25 publications

Association between asymptomatic carotid atherosclerosis and degenerative aortic stenosis

Association between asymptomatic carotid atherosclerosis and degenerative aortic stenosis

Agreement between methods of measurement of mean aortic wall thickness by MRI

Review of Cardiovascular Disease in HIV-Infected Women

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