Interplay of immune modulation, adaptive response and hormesis: Suggestive of threshold for clinical manifestation of effects of ionizing radiation at low doses?

Chaurasia, R.K.; Sapra, B.K.; Aswal, D.K.

doi:10.1016/j.scitotenv.2024.170178

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2024

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Cited by 2 publications

References 208 publications

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Ionizing Radiation for Inclusive Growth

Aswal,

Chandra

2024

Handbook on Radiation Environment, Volume 1

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Ionizing Radiation for Inclusive Growth

Aswal,

Chandra

2024

Handbook on Radiation Environment, Volume 1

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Low-Dose Ionizing Radiation Exposure on Human Male Gametes: Damage or Benefit

Dimitrova,

Hristova,

Petrova

2024

Life

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With the improvement of medical devices for diagnosis and radiotherapy, concerns about the effects of low doses of ionizing radiation are also growing. There is no consensus among scientists on whether they might have beneficial effects on humans in certain cases or pose more risks, making the exposure unreasonable. While the damaging consequences of high-dose radiation have been known since the discovery of radioactivity, low-dose effects present a much bigger investigative challenge. They are highly specific and include radio-adaptive responses, bystander effects, and genomic instability. Current data regarding the consequences of exposure to low-dose radiation on the quality of male gametes and fertility potential are contradictory. The reports suggest two directions: indirect impact on male gametes—through spermatogenesis—or direct effects at low doses on already mature spermatozoa. Although mature gametes are used for observation in both models, they are fundamentally different, leading to varied results. Due to their unique physiological characteristics, in certain cases, exposure of spermatozoa to low-dose ionizing radiation could have positive effects. Despite the findings indicating no beneficial effects of low-dose exposure on male fertility, it is essential to research its impact on mature spermatozoa, as well.

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Interplay of immune modulation, adaptive response and hormesis: Suggestive of threshold for clinical manifestation of effects of ionizing radiation at low doses?

Cited by 2 publications

References 208 publications

Ionizing Radiation for Inclusive Growth

Ionizing Radiation for Inclusive Growth

Low-Dose Ionizing Radiation Exposure on Human Male Gametes: Damage or Benefit

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