We carried out a comprehensive study of the electronic, magnetic, and thermodynamic properties of Ni-doped ZrTe2. High quality Ni0.05ZrTe2 single crystals show the coexistence of charge density waves (CDW, TCDW ≈ 287 K) with superconductivity (Tc ≈ 4.1 K), which we report here for the first time. The temperature dependence of the lower (Hc 1 ) and upper (Hc 2 ) critical magnetic fields both deviate significantly from the behaviors expected in conventional single-gap s-wave superconductors. However, the behaviors of the normalized superfluid density ρs(T ) and Hc 2 (T ) can be described well using a two-gap model for the Fermi surface, in a manner consistent with multiband superconductivity. Electrical resistivity and specific heat measurements show clear anomalies centered near 287 K, suggestive of CDW phase transition. Additionally, electronic structure calculations support the coexistence of electron-phonon multiband superconductivity and CDW due to the compensated disconnected nature of the electron-and hole-pockets at the Fermi surface, with very distinct orbital characters, Fermi velocities, and nesting vectors, as well as the softening of the acoustic phonon modes. Our calculations also suggest that ZrTe2 is a non-trivial topological type-II Dirac semimetal. These findings highlight that Ni-doped ZrTe2 is uniquely important for probing the coexistence of superconducting and CDW ground states in an electronic system with non-trivial topology.