Interobserver variation among pathologists for delineation of tumor on H&amp;E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Jager, E.A.; Willems, Stefan M.; Schäkel, T.; Kooij, N.; Slootweg, Pieter J.; Philippens, M.E.P.; Caldas-Magalhaes, J.; Terhaard, Chris H.J.; Raaijmakers, Cornelis P.J.

doi:10.3109/0284186x.2015.1049661

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…We observed that the HE-based tumor delineations were comparable to the CK-AE1/3-based tumor delineations within two millimeters. The variation between both tumor delineations, quantified using the conformity index (CI), was comparable to the interobserver variation on HE-based tumor delineations as determined by Jager et al who reported a CI of 0.87 [18] .…”

Section: Discussionsupporting

confidence: 64%

“…We also found these discrepancies between HE and cytokeratin based delineations. The discrepancy in delineations for tumor invaded cartilage is in correspondence with the high interobserver variation for delineation of cartilage invasion on HE stained sections [18] . We observed that the tumor tissue was sometimes discontinuously infiltrating the bone marrow and that background staining was high in this area for CK-AE1/3; both might have resulted in the variation between HE and CK-AE1/3 based delineations in the cartilage.…”

Section: Discussionmentioning

confidence: 93%

“…The assumption was made that all microscopic tumor is visible on the HE stained sections as HE-staining is clinically used to assess excision adequacy by evaluating the presence of tumor at the margins of resection. Furthermore, HE-based tumor delineations show a low interobserver variation among pathologists, which indicates high precision of these delineations [18] . However, the question remained whether HE staining is sensitive enough for detecting all microscopic tumor growth.…”

Section: Introductionmentioning

confidence: 98%

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Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin

Ligtenberg

Willems

Ruiter

et al. 2018

Clinical and Translational Radiation Oncology

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

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Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin

Ligtenberg

Willems

Ruiter

et al. 2018

Clinical and Translational Radiation Oncology

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“…In general, the interobserver variation between pathologists was small [15]. However, the irregular shape of this tumor, with a large amount of swelling around the tumor, hampered an accurate delineation on both the H&E sections and the MR images.…”

Section: Discussionmentioning

confidence: 90%

Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

et al. 2016

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Background: Validation of magnetic resonance imaging (MRI) and development of guidelines for the delineation of the gross tumor volume (GTV) is of utmost importance to benefit from the visibility of anatomical details on MR images and to achieve an accurate GTV delineation. In the ideal situation, the GTV delineation corresponds to the histopathologically determined 'true tumor volume'. Consequently, we developed guidelines for GTV delineation of laryngeal and hypopharyngeal tumors on MRI and determined the accuracy of the resulting delineation of the tumor outline on histopathology as gold standard. Material and methods: Twenty-seven patients with T3 or T4 laryngeal/hypopharyngeal cancer underwent a MRI scan before laryngectomy. Hematoxylin and eosin sections were obtained from surgical specimens and tumor was delineated by one pathologist. GTV was delineated on MR images by three independent observers in two sessions. The first session (del1) was performed according to clinical practice. In the second session (del2) guidelines were used. The reconstructed specimen was registered to the MR images for comparison of the delineated GTVs to the tumor on histopathology. Volumes and overlap parameters were analyzed. A target margin needed to assure tumor coverage was determined. Results: The median GTVs (del1: 19.4 cm 3 , del2: 15.8 cm 3 ) were larger than the tumor volume on pathology (10.5 cm 3 ). Comparable target margins were needed for both delineation sessions to assure tumor coverage. By adding these margins to the GTVs, the target volumes for del1 (median: 81.3 cm 3 ) were significantly larger than for del2 (median: 64.2 cm 3 ) (p 0.0001) with similar tumor coverage. Conclusions: In clinical radiotherapy practice, the delineated GTV on MRI is twice as large as the tumor volume. Validated delineation guidelines lead to a significant decrease in the overestimation of the tumor volume.

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StructuRegNet: Structure-Guided Multimodal 2D-3D Registration

Leroy,

Cafaro,

Gessain

et al. 2023

Lecture Notes in Computer Science

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Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?

Abstract: P. J. Raaijmakers (2016) Interobserver variation among pathologists for delineation of tumor on H&E-sections of laryngeal and hypopharyngeal carcinoma. How good is the gold standard?, Acta Oncologica, 55:3, 391-395,

Cited by 5 publications

References 12 publications

Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin

Verification of HE-based CTV in laryngeal and hypopharyngeal cancer using pan-cytokeratin

Validated guidelines for tumor delineation on magnetic resonance imaging for laryngeal and hypopharyngeal cancer

StructuRegNet: Structure-Guided Multimodal 2D-3D Registration

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