International quality of life assessment (IQOLA) project

Aaronson, Neil K.; Acquadro, C.; Alonso, Jordi; Apolone, Giovanni; Bucquet, D.; Bullinger, Monika; Bungay, Kathleen M.; Fukuhara, Shunichi; Gandek, Barbara; Keller, San; Razavi, Darius; Sanson‐Fisher, Rob; Sullivan, Marianne; Wood-Dauphinée, Sharon; Wagner, Anita K.; Ware, John E.

doi:10.1007/bf00434949

Cited by 530 publications

(259 citation statements)

References 13 publications

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“…Postoperative quality of life was assessed by the validated psychometric questionnaire SF-36, which is based on the American short-form-36 health survey [36,37] and has been psychometrically validated [1,5,10]. As the SF-36 score considers 36 items in eight different scales of subjective physical and mental health as well as social and emotional aspects, it is generally considered to reliably assess disease-related quality of life.…”

Section: Oncological Outcomementioning

confidence: 99%

Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy

Melcher

Disch

Khodadadyan-Klostermann

et al. 2007

Eur Spine J

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Primary malignant spinal tumors and solitary vertebral metastases of selected tumor entities in the thoracolumbar spine are indications for total en bloc spondylectomy (TES). This study aimed to describe our oncological and surgical management and to analyze the treatment results by management with TES for extra-and intracompartmental solitary spinal metastases and primary malignant vertebral bone tumors. In 15 patients (3 malignant bone tumors and 12 solitary metastases), tumors were distributed in the thoracic (n = 8) and lumbar (n = 7) spine. Tumors were classified as intra-(n = 8) and extracompartmental (n = 7). All patients underwent TES via a laterally extended posterior approach followed by dorsoventral reconstruction. Function and quality of life were assessed by Oswestry disability index (ODI) and SF-36 score. At follow-up (100%; mean: 33 ± 22 months), 11 patients had no evidence of disease. Two patients were alive with the disease and two were dead of the disease (no primary bone tumors). Histology revealed negative margins (R0) in all patients with wide (n = 11) and marginal (n = 4) resections. Two patients developed pulmonal metastases of which they died at 4 and 16 months of survival. No local recurrence was observed. Major complications did not occur. TES resulted in an acceptable outcome in the quality of life and function. TES is a demanding procedure reaching wide to marginal resections in a curative approach. In conjunction with multimodal therapies, local recurrences can effectively be prevented while control of distant disease needs to be improved. Proper selection of adequate patients combined with careful surgical planning are prerequisites for low complication rates, acceptable function and improved overall prognosis.

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Section: Oncological Outcomementioning

confidence: 99%

Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy

Melcher

Disch

Khodadadyan-Klostermann

et al. 2007

Eur Spine J

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“…Questionnaires that were not already available in Spanish were translated and backtranslated according to standard techniques (24).…”

Section: Information Obtained During the Enrollment Evaluationmentioning

confidence: 99%

Longitudinal study of negative workplace events among employed rheumatoid arthritis patients and healthy controls

Mancuso¹,

Rincon²,

Sayles³

et al. 2005

Arthritis & Rheumatism

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Objective. Most studies of employment in patients with rheumatoid arthritis (RA) have focused on job loss. Less is known about workplace events in patients who continued to work. The goal of this longitudinal study was to compare the incidence of negative workplace events between employed patients with RA and healthy controls. Methods. Participants completed the work domains of the Psychiatric Epidemiology Research Interview Life EventsScale and the Inventory of Small Life Events Scale measuring major and minor workplace events. Events were compared between groups according to psychosocial, clinical, and job characteristics. Results. A total of 122 patients with RA and 122 healthy controls were enrolled with similar demographic and occupational characteristics. There were no differences in percentages of patients and controls who had at least 1 major (35% versus 31%) or 1 minor (48% versus 55%) negative event. For patients with RA, negative events were associated with having more pain, more fatigue, more social stress, and less job autonomy (P < 0.05). For controls, in addition to social stress, negative events were associated with job characteristics, functional status, and social support (P < 0.05). Conclusion. A comparable number of patients with RA and controls had negative workplace events. In addition to the well-known contributions of job autonomy and pain, social stress and fatigue also were found to be important variables related to negative events in patients with RA. These potentially modifiable variables have not been fully evaluated with respect to long-term employment in these patients.

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“…¼ 10) for the general United States population (Ware et al, 1994). We used a validated Dutch version of the SF-36 (Aaronson et al, 1992(Aaronson et al, , 1998) with a time frame (reference period) of 1 week.…”

Section: Appendix a Health-status Measuresmentioning

confidence: 99%

Impact of screening for breast cancer in high-risk women on health-related quality of life

et al. 2004

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The effectiveness of intensive surveillance in women at high risk for breast cancer due to a familial or genetic predisposition is uncertain and is currently being evaluated in a Dutch magnetic resonance imaging (MRI) screening (MRISC) study, in which annual imaging consists of mammography and MRI. Unfavourable side effects on health-related quality of life may arise from this screening process. We examined the short-term effects of screening for breast cancer in high-risk women on generic health-related quality of life and distress. A total of 519 participants in the MRISC study were asked to complete generic health-status questionnaires (SF-36, EQ-5D) as well as additional questionnaires for distress and items relating to breast cancer screening, at three different time points around screening. The study population showed significantly better generic health-related quality of life scores compared to age-/sexadjusted reference scores from the general population. Neither generic health-related quality of life scores nor distress scores among the study sample (n ¼ 334) showed significant changes over time. The impact of the screening process on generic health status did not differ between risk categories. Relatively more women reported mammography as quite to very painful (30.1%) compared to MRI. Anxiety was experienced by 37% of the women undergoing MRI. We conclude that screening for breast cancer in high-risk women does not have an unfavourable impact on short-term generic health-related quality of life and general distress. In this study, high-risk women who opted for regular breast cancer screening had a better health status than women from the general population.

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International quality of life assessment (IQOLA) project

Cited by 530 publications

References 13 publications

Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy

Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy

Longitudinal study of negative workplace events among employed rheumatoid arthritis patients and healthy controls

Impact of screening for breast cancer in high-risk women on health-related quality of life

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