International progress in cancer gene therapy

Guinn, Barbara; Mulherkar, Rita

doi:10.1038/cgt.2008.66

Cited by 36 publications

(26 citation statements)

References 74 publications

(61 reference statements)

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“…With the expectation of improving therapeutic efficacy, gene therapy is being studied as a possible therapeutic modality [14]. The tumorigenesis and progression of gastric cancer are far from being fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Lentivirus-delivered Krüppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo

Liu

et al. 2011

Tumor Biol.

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We found that the transcription factor Krüppel-like factor 8 (KLF8) was highly expressed in gastric cancer tissues and cell lines compared with adjacent noncancerous regions and gastric epithelial mucosa cells. We employed a lentivirus-mediated RNAi technique to knockdown KLF8 expression in gastric cancer cell line SGC7901 and observed its effects on cell growth in vitro and in vivo. Knockdown of KLF8 inhibited SGC7901 cell proliferation, promoted cell apoptosis, inhibited the tumorigenicity of SGC7901 cells, and significantly decreased tumor growth when the cells were injected into nude mice. These results indicated that overexpression of KLF8 may influence the biological behavior of SGC7901 gastric cancer cells. Knockdown of KLF8 expression by lentivirus-delivered siRNA may be useful as a therapeutic agent for the treatment of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Lentivirus-delivered Krüppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo

Liu

et al. 2011

Tumor Biol.

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“…Gene therapy is a promising approach for the treatment of both acquired and inherited diseases, which are lacking effective drug treatments 1–3. The success of gene therapy is largely dependent on the development of vectors capable of effectively delivering foreign genes into targeted cells.…”

Section: Introductionmentioning

confidence: 99%

Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer

Kurosaki

Yamashita

Aki

et al. 2011

Journal of Pharmaceutical Sciences

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“…Cytotoxicity assessments are a necessary stage of preclinical tests of drug candidates, including the increasingly used gene therapeutics, that is, genetic material encoding therapeutic proteins or RNA [11][12][13][14][15]. However, the in vitro test systems currently in use do not allow for the assessment of the cytotoxic effects of gene therapeutics, since they have been developed for testing exogenous substances and do not provide the means for the introduction of genetic material into a cell.…”

mentioning

confidence: 99%

Evaluation of the toxic effects evoked by the transient expression of protease genes from human pathogens in HEK293 cells

Shubin

Lunina

Шедова

et al. 2013

Appl Biochem Microbiol

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A method for the in vitro evaluation of the toxic effects occurring in human cell lines upon the expression of genes from a range of pathogens is proposed. The method is based on the transient expression of the genes in the HEK293 cell line. Induction of cell death upon the expression of the gene coding for pro tease 3C from the human hepatitis A virus has been demonstrated for the first time using the method pro posed. Expression of the gene coding for protease 2A from human poliovirus has also been shown to induce cell death, while cathepsins B and D did not have a cytotoxic effect on the culture used.

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International progress in cancer gene therapy

Cited by 36 publications

References 74 publications

Lentivirus-delivered Krüppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo

Lentivirus-delivered Krüppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo

Secure and effective gene vector of polyamidoamine dendrimer pharmaceutically modified with anionic polymer

Evaluation of the toxic effects evoked by the transient expression of protease genes from human pathogens in HEK293 cells

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