2008
DOI: 10.1590/s0037-86822008000300020
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International meeting: new diagnostic tests are urgently needed to treat patients with Chagas disease

Abstract: Trypanosoma cruzi infection is often not detected early on or actively diagnosed, partly because most infected individuals are either asymptomatic or oligosymptomatic. Moreover, in most places, neither blood banks nor healthcare units offer diagnostic confirmation or treatment access. By the time patients present clinical manifestations of advanced chronic Chagas disease, specific treatment with current drugs usually has limited effectiveness. Better-quality serological assays are urgently needed, especially r… Show more

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Cited by 38 publications
(23 citation statements)
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“…There is no consensus regarding optimal treatment duration which varies from 30 days to 90 days depending on the tolerance to the drugs. There is also no reliable test of cure that can be used to monitor the effectiveness of treatment in chronic CD patients [13]. …”
Section: Introductionmentioning
confidence: 99%
“…There is no consensus regarding optimal treatment duration which varies from 30 days to 90 days depending on the tolerance to the drugs. There is also no reliable test of cure that can be used to monitor the effectiveness of treatment in chronic CD patients [13]. …”
Section: Introductionmentioning
confidence: 99%
“…These tests also must be highly sensitive, specific, and easy to use (22). The need for highly sensitive and specific RDTs was reiterated in 2010 when the 63rd World Health Assembly outlined, through its resolution WHA63.20, the need "to promote and encourage operational research on control of Chagas disease in order to establish systems of early detection" and "to integrate, at the primary health care level, diagnosis and treatment of Chagas disease in patients in both acute and chronic phases of the disease," in countries that are endemic and nonendemic for the disease (23).…”
mentioning
confidence: 99%
“…(ii) high immunogenicity regardless the clinical form of Chagas disease and (iii) stability and adaptability to quality-control tests to guarantee reproducibility [13], [49], [50]. We believe that the antigens identified in this study meet all these criteria.…”
Section: Discussionmentioning
confidence: 75%
“…The lack of highly accurate methods to diagnose Chagas disease hampers the correct identification and treatment of infected individuals and restricts the evaluation of effectiveness of any initiative aiming at blocking transmission or vaccination in endemic countries [13], [15]. Additionally, reports of blood transfusion transmission in the USA, Spain and Canada, countries that receive a high contingency of Latin-American immigrants also highlights the importance of an accurate diagnostic test to identify Chagas disease infection in samples from blood banks of non-endemic countries [5][8], [44], [45].…”
Section: Discussionmentioning
confidence: 99%
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