Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice

Calpe-López, Claudia; Martínez-Caballero, M. Ángeles; García-Pardo, María Pilar; Aguilar, M.A.

doi:10.1016/j.physbeh.2022.113916

Cited by 15 publications

(8 citation statements)

References 61 publications

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“…In the TST, which puts mice in an inescapable but moderately stressful situation, immobility is considered to be the lack of escape-related behavior. Although chronic SD stress is known to cause increased immobility in the TST [78,79], with our protocol, in which male mice experience only 4 SD separated by 72 h, we did not observe an increase in immobility time in the TST in defeated adult male mice [80]. Most studies in male rodents report that a short-period paradigm of SD is more likely to result in the phenotype of anxiety [81] since other reports have indicated that 20 days of social stress is required to develop depression [82].…”

Section: Vsd Induce Anxiety-and Anhedonic-like Behaviorscontrasting

confidence: 71%

Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice

et al. 2023

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Stress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed and validated. The aim of the present study was to unravel the long-lasting effects of vicarious social defeat (VSD) on the conditioned rewarding effects of cocaine and ethanol intake in female mice. Although VSD seems to be a good model for inducing behavioral and physiologic endophenotypes induced by stress, there are no studies to date that characterize the effect of VSD on cocaine or alcohol use. The results confirm that VSD females showed an increase in corticosterone levels after a vicarious experience while also displaying an increase in anxiety- and anhedonic-like behaviors. Three weeks after the last VSD, vicariously defeated female mice showed an increased developed preference for a non-effective dose of cocaine in the conditioned place preference (CPP) paradigm and showed an increase in ethanol intake. Our results suggest that female mice vicariously experience a state of distress through the social observation of others suffering from adverse events, confirming the use of VSD as a valid model to study the response to social stress in females. The fact that VSD in females induced a comparable behavioral phenotype to that observed in physically defeated males could indicate a relationship with the higher rate of psychopathologies observed in women. Notwithstanding, more studies are needed to dissect the neurobiological and behavioral peculiarities of the female response to social stress.

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Section: Vsd Induce Anxiety-and Anhedonic-like Behaviorscontrasting

confidence: 71%

Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice

et al. 2023

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“…RSD and MIA mimic some of the behavioral effects of bullying in humans and maternal infection, respectively ( Björkqvist, 2001 ; Brown and Meyer, 2018 ; Careaga et al, 2017 ). In accordance with other studies ( Calpe-López et al, 2022 ; Shimizu et al, 2020 ; Warren et al, 2014 ), we found that within a week after the adolescent RSD protocol, rats displayed a reduction in social behavior and increased anxiety as indicated by a reduced time spent playing with another rat and a reduced number of entries in the open arm of the EPM, respectively. These effects were not observed in MIA offspring exposed to the RSD protocol, suggesting a protective effect of MIA.…”

Section: Discussionsupporting

confidence: 93%

Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats

Guerrin,

Prasad,

Vazquez-Matias

et al. 2023

Neurobiology of Stress

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“…Arousing stimuli in rodents have been shown to elicit spontaneous grooming bouts that are more frequent but of shorter duration (Fernández-Teruel & Estanislau, 2016; Kalueff et al, 2016). In the absence of overall difference in the time invested in grooming, it is difficult to appreciate the effects of exercise on behaviors suggestive of depression, especially as parameters in the tail suspension test were unaffected by exercise, in line with previous reports (Calpe-López et al, 2022).…”

Section: Discussionmentioning

confidence: 65%

Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice

Williams

Szyszkowicz

Osborne

et al. 2022

Preprint

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Physical exercise has been positioned as a promising strategy to prevent and/or alleviate anxiety and depression, but the mechanisms underlying its effects on mental health have yet to be entirely determined. Although the prevalence of depression and anxiety in women is about twice that of men, very few studies have examined whether physical exercise could affect mental health differently according to sex. This study examined, in mice, the sex-specific effects of voluntary exercise on body weight, depressive- and anxiety-like behaviors, as well as different markers along the gut microbiota-immune-brain axis. Male and female C57BL/6N mice had voluntary access to running wheels in their home-cages for 24 days or were left undisturbed in identical home-cages without running wheels. Behaviors were then examined in the open field, Splash, elevated plus maze, and tail suspension tests. Gene expression of pro-inflammatory cytokines, microglia activation-related genes, and tight junction proteins was determined in the jejunum and the hippocampus, while microbiota composition and predicted function were verified in cecum contents. Voluntary exercise limited weight gains, reduced anxiety-like behaviors, and altered grooming patterns in males exclusively. Although the exercise intervention resulted in changes to brain inflammatory activity and to cecal microbiota composition and inferred function in both sexes, reductions in the jejunal expression of pro-inflammatory markers were observed in females only. These findings support the view that voluntary exercise, even when performed during a short period, is beneficial for mental and intestinal health and that its sex-specific effects on behavior could be, at least in part, mediated by the gut microbiota-immune-brain axis.

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Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice

Cited by 15 publications

References 61 publications

Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice

Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice

Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats

Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice

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