Intermittent versus continuous androgen suppression for prostatic cancer

Intermittent hormonal therapy in the treatment of metastatic prostate cancer: a randomized trial

“…To our knowledge, this is the first designed trial devoted to only patients with metastases [22]. In this study, no statistical difference in either OS (42.2 vs 52 months) or PFS (20.7 vs 15.1 months) was shown between intermittent ADT and continuous ADT.…”

Intermittent hormonal therapy in the treatment of metastatic prostate cancer: a randomized trial

“…To our knowledge, this is the first designed trial devoted to only patients with metastases [22]. In this study, no statistical difference in either OS (42.2 vs 52 months) or PFS (20.7 vs 15.1 months) was shown between intermittent ADT and continuous ADT.…”

Sixth Joint Meeting of J-CaP and CaPSURE--A Multinational Perspective on Prostate Cancer Management and Patient Outcomes

“…He outlined the findings of the Cochrane Review published in 2007, which included five studies comparing continuous androgen deprivation (CAD) and intermittent androgen deprivation (IAD) in a total of 1382 patients with advanced (T3 or T4) prostate cancer. Based on this analysis, the overall conclusion at that time was that more research was needed (15). He noted that data from randomized, controlled trials comparing IAD with CAD were limited by small sample size and short duration.…”

Receipt of National Comprehensive Cancer Network guideline‐concordant prostate cancer care among African American and Caucasian American men in North Carolina

“…Although few men were receiving ADT as their initial treatment, it does not appear that physicians were delaying ADT until symptoms arose, as has been suggested may be appropriate. 23 Rather, overuse of aggressive care-either surgery for those with nodal involvement only or radiation for those with metastasesled to most of the guideline discordance observed. However, the 2004 NCCN guidelines suggest that surgery may be appropriate for those with T3 stage and nodal involvement 10 ; thus, some of this care may be clinically appropriate.…”

Intermittent hormonal therapy in the treatment of metastatic prostate cancer: a randomized trial

“…To our knowledge, this is the first designed trial devoted to only patients with metastases [22]. In this study, no statistical difference in either OS (42.2 vs 52 months) or PFS (20.7 vs 15.1 months) was shown between intermittent ADT and continuous ADT.…”

Sixth Joint Meeting of J-CaP and CaPSURE--A Multinational Perspective on Prostate Cancer Management and Patient Outcomes

“…He outlined the findings of the Cochrane Review published in 2007, which included five studies comparing continuous androgen deprivation (CAD) and intermittent androgen deprivation (IAD) in a total of 1382 patients with advanced (T3 or T4) prostate cancer. Based on this analysis, the overall conclusion at that time was that more research was needed (15). He noted that data from randomized, controlled trials comparing IAD with CAD were limited by small sample size and short duration.…”

Receipt of National Comprehensive Cancer Network guideline‐concordant prostate cancer care among African American and Caucasian American men in North Carolina

“…Although few men were receiving ADT as their initial treatment, it does not appear that physicians were delaying ADT until symptoms arose, as has been suggested may be appropriate. 23 Rather, overuse of aggressive care-either surgery for those with nodal involvement only or radiation for those with metastasesled to most of the guideline discordance observed. However, the 2004 NCCN guidelines suggest that surgery may be appropriate for those with T3 stage and nodal involvement 10 ; thus, some of this care may be clinically appropriate.…”

Intermittent hormonal therapy in the treatment of metastatic prostate cancer: a randomized trial

“…To our knowledge, this is the first designed trial devoted to only patients with metastases [22]. In this study, no statistical difference in either OS (42.2 vs 52 months) or PFS (20.7 vs 15.1 months) was shown between intermittent ADT and continuous ADT.…”

Sixth Joint Meeting of J-CaP and CaPSURE--A Multinational Perspective on Prostate Cancer Management and Patient Outcomes

“…He outlined the findings of the Cochrane Review published in 2007, which included five studies comparing continuous androgen deprivation (CAD) and intermittent androgen deprivation (IAD) in a total of 1382 patients with advanced (T3 or T4) prostate cancer. Based on this analysis, the overall conclusion at that time was that more research was needed (15). He noted that data from randomized, controlled trials comparing IAD with CAD were limited by small sample size and short duration.…”

Receipt of National Comprehensive Cancer Network guideline‐concordant prostate cancer care among African American and Caucasian American men in North Carolina

“…Although few men were receiving ADT as their initial treatment, it does not appear that physicians were delaying ADT until symptoms arose, as has been suggested may be appropriate. 23 Rather, overuse of aggressive care-either surgery for those with nodal involvement only or radiation for those with metastasesled to most of the guideline discordance observed. However, the 2004 NCCN guidelines suggest that surgery may be appropriate for those with T3 stage and nodal involvement 10 ; thus, some of this care may be clinically appropriate.…”