Cell Reports volume 5, issue 2, P521-530 2013 DOI: 10.1016/j.celrep.2013.09.007 View full text Has erratum 2013-10-31
Martin Depken, Juan M.R. Parrondo, Stephan W. Grill

Abstract: Normal cellular function relies on the efficient and accurate readout of the genetic code. Single-molecule experiments show that transcription and replication are highly intermittent processes that are frequently interrupted by polymerases pausing and reversing directions. Although intermittent dynamics in replication are known to result from proofreading, their origin and significance during transcription remain controversial. Here, we theoretically investigate transcriptional fidelity and show that the kinet…

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