Intermittent theta-burst transcranial magnetic stimulation for treatment of Parkinson disease

Abstract

Objective: To investigate the safety and efficacy of intermittent theta-burst stimulation (iTBS) in the treatment of motor symptoms in Parkinson disease (PD).Background: Progression of PD is characterized by the emergence of motor deficits, which even-

Non-invasive brain stimulation for Parkinson’s disease: Current concepts and outlook 2015

“…The DLPFC is the prime target of high-frequency rTMS for the treatment of refractory depression and currently the only FDA-approved therapeutic application of rTMS in clinical practice. The repeated stimulation of the DLPFC improves mood (Benninger et al, 2011;Pal, Nagy, Aschermann, Balazs, & Kovacs, 2010) comparable to antidepressants (Fregni et al, 2004) in PD. The international consortium concluded a probable antidepressant effect of high-frequency-rTMS of the left DLPFC in Parkinson's disease (Level B) (Lefaucheur et al, 2014).…”

“…The international consortium concluded a possible anti-parkinsonian effect of high-frequency (5-25 Hz) rTMS of bilateral M1 (Level C). Despite evidence of a superior efficacy of intermittent Theta-Burst stimulation (iTBS) over conventional rTMS protocols (Huang, Edwards, Rounis, Bhatia, & Rothwell, 2005), a RCT of repeated iTBS of both M1 and DLPFC found no beneficial effects except for mood (Benninger et al, 2011). A RCT of repeated 50 Hz rTMS of both M1 did not show efficacy either (Benninger et al, 2012).…”

“…DBS (R. Dauper et al, 2002), high-frequency (up to 50 Hz) rTMS (Benninger et al, 2012;Gilio et al, 2002;Lefaucheur et al, 2004;Siebner et al, 2000), and low-frequency rTMS (Lefaucheur et al, 2004), modulate the CSP which suggests activation of common mechanisms. Yet, the functional significance of the CSP remains unknown, and the CSP may ultimately not correlate with motor function (Benninger et al, 2011;Benninger et al, 2012;Berardelli, Rona, Inghilleri, & Manfredi, 1996;Ridding, Inzelberg, & Rothwell, 1995) or other neurophysiological measures (Lefaucheur et al, 2004).…”

Repetitive transcranial magnetic stimulation in neurology and psychiatry

“…[60][61][62][63], не позволяю-щие сделать заключение об однозначной эффективности высокочастотной односторонней стимуляции при БП.…”

Combining functional imaging with brain stimulation in Parkinson's disease

“…rTMS at 1 Hz may also elicit a sustained or prolonged change in PD cortex excitability as revealed by a longer silent period duration (Filipovic et al, 2010) suggestive of an infl uence on GABA activity. However, besides these positive reports, others have failed to show any improvement and have thus rejected claims for a benefi cial role of rTMS in PD motor symptoms (Benninger et al, 2011;Boylan et al, 2001;del Olmo et al, 2007;Ghabra et al, 1999;Tergau et al, 1999). A number of reasons may account for these discrepancies, such as methodological differences, patient selection and the role of medication.…”