Intermittent fasting, adipokines, insulin sensitivity, and hypothalamic neuropeptides in a dietary overload with high-fat or high-fructose diet in mice

Spezani, Renata; Silva, Renata Ribeiro da; Martins, Fabiane Ferreira; Marinho, Thatiany de Souza; Águila, Márcia Barbosa; Mandarim-de-Lacerda, Carlos Alberto

doi:10.1016/j.jnutbio.2020.108419

Cited by 25 publications

(26 citation statements)

References 62 publications

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“…The neonatal exposure to a hypercaloric diet leads to a higher body mass in adulthood (Choi, 2018). Then, the hypothalamus is directly involved with obesity (Velloso, 2012), and the adult offspring of dams fed a highfat diet showed exaggerated feeding response to neuropeptide Y, eating twice as much as control animals (Kozak et al, 2000;Spezani et al, 2020).…”

Section: Maternal Obesitymentioning

confidence: 99%

Nutritional Research and Fetal Programming: Parental Nutrition Influences the Structure and Function of the Organs

2021

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Section: Maternal Obesitymentioning

confidence: 99%

Nutritional Research and Fetal Programming: Parental Nutrition Influences the Structure and Function of the Organs

2021

Self Cite

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“…Previous investigations in human and animal models analyzed the effects of IF on leptin and insulin sensitivity ( 26 , 27 ), inflammatory pathways ( 28 , 29 ), the brain-microbiota axis ( 30 , 31 ), circadian cycle ( 32 , 33 ), and autophagic pathway ( 34 ). All these factors seem to be related to adaptations in POMC and AgRP neuropeptides ( 35 ) that can improve energy homeostasis through pathways that are not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, although several studies show that IF protocols can reduce plasma levels of pro-inflammatory proteins in obese or overweight individuals ( 27 , 116 ), few studies have assessed the adaptation of inflammatory proteins in the hypothalamic region. Spezani et al ( 27 ) evaluated the effects of a 24-h fasting protocol interspersed with days of ad libitum high-fructose diet in mice with induced obesity (eight-week protocol with a high-fructose diet). After 4 weeks of intervention, a reduction in the expression of hypothalamic SOCS3 was observed.…”

Section: Introductionmentioning

confidence: 99%

“…After 4 weeks of intervention, a reduction in the expression of hypothalamic SOCS3 was observed. However, animals fed a standard diet and submitted to an IF protocol showed an increase in SOCS3 compared to control animals with a standard diet without applying the IF protocol ( 27 ). Controversially, the study of Zangh et al ( 117 ) did not observe changes in the expression of hypothalamic SOCS3 or alteration in plasma insulin in female mice fed with a standard diet and submitted to chronic IF protocols for 24 h performed only one to two times a week, during a period of 13 or 42 days.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding animal studies, Spezani et al ( 27 ) evaluated the effects of IF for 24 h. The authors observed that obese mice submitted to fasting curiously showed a greater expression of hypothalamic TNFα when compared to the control group. Therefore, the data are still contradictory, and further studies are needed to assess the content and expression of TNFα, specifically in the hypothalamus of obese animals submitted to different IF protocols.…”

Section: Introductionmentioning

confidence: 99%

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Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption

et al. 2022

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Intermittent fasting (IF) is a popular intervention used to fight overweight/obesity. This condition is accompanied by hypothalamic inflammation, limiting the proper signaling of molecular pathways, with consequent dysregulation of food intake and energy homeostasis. This mini-review explored the therapeutic modulation potential of IF regarding the disruption of these molecular pathways. IF seems to modulate inflammatory pathways in the brain, which may also be correlated with the brain-microbiota axis, improving hypothalamic signaling of leptin and insulin, and inducing the autophagic pathway in hypothalamic neurons, contributing to weight loss in obesity. Evidence also suggests that when an IF protocol is performed without respecting the circadian cycle, it can lead to dysregulation in the expression of circadian cycle regulatory genes, with potential health damage. In conclusion, IF may have the potential to be an adjuvant treatment to improve the reestablishment of hypothalamic responses in obesity.

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Neuroprotective effects of nuciferine on high‐fat diet‐induced cognitive dysfunction in obese mice: Role of insulin resistance, neuroinflammation, and oxidative stress

Zhu,

Hao,

et al. 2024

Food Frontiers

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High‐fat diets (HFDs) trigger oxidative stress, insulin resistance (IR), and inflammatory responses in the body, leading to cognitive dysfunction. This study aimed to elucidate the effects of nuciferine on HFD‐induced IR and cognitive impairment in the central nervous system of obese mice and further identify the possible underlying mechanisms. In behavioral experiments, nuciferine administration increased the total distance moved, the number of times mice entered the open arm, the duration of open dwell time, and the number of alternations while shortening the latency to escape. Nuciferine suppressed HFD‐induced synaptic structure damage, as evidenced by the increased expressions of neurotrophic factor BDNF and synaptic function proteins SYN, SNAP‐25, and PSD‐95. In addition, nuciferine effectively ameliorated HFD‐induced IR by IRS/PI3K/AKT pathway, alleviated HFD‐induced neurological damage through AMPK/SIRT1 pathway, and improved cognitive impairment via the Aβ‐tau‐neuroinflammation axis. Therefore, nuciferine could be a new food‐derived neuroprotective agent to counteract HFD‐induced damage.

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Intermittent fasting, adipokines, insulin sensitivity, and hypothalamic neuropeptides in a dietary overload with high-fat or high-fructose diet in mice

Cited by 25 publications

References 62 publications

Nutritional Research and Fetal Programming: Parental Nutrition Influences the Structure and Function of the Organs

Nutritional Research and Fetal Programming: Parental Nutrition Influences the Structure and Function of the Organs

Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption

Neuroprotective effects of nuciferine on high‐fat diet‐induced cognitive dysfunction in obese mice: Role of insulin resistance, neuroinflammation, and oxidative stress

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