Intermediary Metabolism of Phenylalanine and Tyrosine in Diffuse Collagen Diseases

Nishimura, Naoyuki

doi:10.1001/archderm.1959.01560220076016

Cited by 23 publications

(2 citation statements)

References 22 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the first time disorders in tyrosine metabolism in collagen diseases were found by Japanese physicians [7] in 1958, but later such disorders were found by different authors in other diseases.Our work was performed within three years in the Clinic of Therapy and Occupational Diseases, First Moscow Medical Institute. Eighty patients with SLE were observed during hospitalizations, some of them were hospitalized repeatedly.…”

Section: Gc Preparations and Tyrosine Content In Systemic Lupus Erythmentioning

confidence: 99%

Can We Tame Glucocorticoids? Blood Tyrosine as a New Laboratory Test

Rass¹

2016

J Biomol Res Ther

View full text Add to dashboard Cite

Glucocorticoid (GC) preparations are used in medicine for about 70 years as the most powerful anti-inflammatory drugs also possessing immunosuppressive, anti-allergic and antitoxic properties. However, application of these unique preparations is associated with nearly inevitable serious adverse effects and a difficulty of their withdrawal. It is very important that the adverse effects are caused not by toxic action of GC preparations but by their hormonal nature. Glucocorticoid hormones directly or indirectly control virtually all metabolic and physiological processes in the body. However, for these virtually omnipresent and vitally important hormones there is no representative specific index of action similar to blood content of glucose for insulin. The present paper considers specific features of tyrosine metabolism that allows us to consider changes in blood tyrosine content as manifestation of regulatory action of GCs. Changes in blood tyrosine content were compared with using GC preparations in two typical cases: in systemic lupus erythematosus and in congenital adrenal virilizing dysfunction in children. Blood tyrosine behavior was also considered in rats after adrenalectomy and on injecting them with hydrocortisone. Based on these observations, it is proposed to use blood content of tyrosine as a laboratory test for reasonable prescribing GC preparations and monitoring their dose. Blood tyrosine behavior in comparison with adrenocortical response is also considered in influenza.

show abstract

Section: Gc Preparations and Tyrosine Content In Systemic Lupus Erythmentioning

confidence: 99%

Can We Tame Glucocorticoids? Blood Tyrosine as a New Laboratory Test

Rass¹

2016

J Biomol Res Ther

View full text Add to dashboard Cite

show abstract

“…In the late 1950s Japanese researchers of the Nishimura group found increased levels of tyrosine in blood and urine of patients with collagen diseases (Nishimura et al, 1958;Nishimura et al, 1961) and supposed that disorders in tyrosine catabolism could be a biochemical basis of these diseases. These reports stimulated intensive studies on tyrosine catabolism in collagenoses and some other diseases, especially in Russia.…”

Section: Blood Tyrosine Levels In Some Non-endocrine Diseasesmentioning

confidence: 99%