Abstract:Interleukin-6 (IL-6) and interleukin-11 are two important pleiotropic cytokines, both of which signal through a homodimer of the b-receptor gp130. Specificity is gained through the unique, nonsignaling a-receptors IL-6R and IL-11R. Soluble variants of IL-6R and IL-11R also exist. Both membrane-bound receptors can be cleaved by the metalloprotease ADAM10. Here, we use ten different chimeric receptors consisting of different parts of IL-6R and IL-11R and analyze their susceptibility toward cleavage by ADAM10. A… Show more
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