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Cited by 114 publications
(104 citation statements)
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References 76 publications
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“…Recent reviews have discussed the possible use of flavonoids in the treatment of neurodegenerative diseases (Jäger and Saaby, 2011;Jones et al, 2012;Solanki et al, 2015). Strangely, IL-33 has been reported to improve functional recovery after contusion spinal cord injury in a mouse model (Pomeshchik et al, 2015) and to attenuate experimental autoimmune uveitis . These apparently opposite results may be attributable to species differences or the involvement of different IL-33 isoforms (Villarreal and Weiner, 2015).…”
Section: Il-33 In Autoimmune and Inflammatory Disordersmentioning
confidence: 99%
“…Recent reviews have discussed the possible use of flavonoids in the treatment of neurodegenerative diseases (Jäger and Saaby, 2011;Jones et al, 2012;Solanki et al, 2015). Strangely, IL-33 has been reported to improve functional recovery after contusion spinal cord injury in a mouse model (Pomeshchik et al, 2015) and to attenuate experimental autoimmune uveitis . These apparently opposite results may be attributable to species differences or the involvement of different IL-33 isoforms (Villarreal and Weiner, 2015).…”
Section: Il-33 In Autoimmune and Inflammatory Disordersmentioning
confidence: 99%
“…IL‐33 was shown to reduce secondary injury and improve functional recovery in a mouse contusive SCI model 76. IL‐33 reduced TNF‐α expression, cytotoxic TNF‐α + /CD4 + cells, and M1 polarization, increased M2 polarization and T‐regulatory cells, and induced a shift toward Th2.…”
Section: Roles Of Inflammatory Cytokines In Sci Repairmentioning
confidence: 99%
“…In spinal cord injury models, IL-33 mediates neuronal protection via type 2 immune responses [65,66]. Although IL-33 is likely to be neuroprotective in stroke and spinal cord injury models, the development of an effective strategy for the delivery of recombinant protein to the injured brain tissue remains a challenging issue that awaits further study.…”
Section: Central Nervous Systemmentioning
confidence: 99%