Interleukin 33 Mediates Type 2 Immunity and Inflammation in the Central Nervous System of Mice Infected With Angiostrongylus cantonensis

Peng, Hui; Sun, Rui; Zhang, Qixian; Zhao, Jia; Wei, Jie; Zeng, Xiaofeng; Zheng, Haixue; Wu, Zhongdao

doi:10.1093/infdis/jis682

Cited by 32 publications

(25 citation statements)

References 27 publications

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Section: Role Of Il-33/st2 In Helminth Diseasesmentioning

confidence: 90%

“…Finally, IL-33 and ST2 are overexpressed in the brain in mice infected with Angiostrongylus cantonensis (80,81). In this model, splenocytes and mononuclear brain cells responded to IL-33 through production of IL-5 and IL-13, both of which contribute to eosinophilic meningitis induced by A. cantonensis (80,81). The injection of a monoclonal anti-ST2 antibody 3 days postinfection with further injections every 5 days led to a significant reduction of IL-5 blood levels and of eosinophil influx in the meninges (82).…”

Section: Role Of Il-33/st2 In Helminth Diseasesmentioning

confidence: 97%

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Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

et al. 2015

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Section: Role Of Il-33/st2 In Helminth Diseasesmentioning

confidence: 90%

Section: Role Of Il-33/st2 In Helminth Diseasesmentioning

confidence: 97%

Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

et al. 2015

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“…Conversely, IL-33 mediates pathogenic eosinophilic responses in Angiostrongylus cantonensis infection-induced meningitis, and antibodies against ST2 or IL-33 blockade reduce disease severity [66][67][68]. In the model of experimental autoimmune encephalomyelitis (EAE), IL-33 blockade mediates both pathogenic and protective roles [69][70][71].…”

Section: Central Nervous Systemmentioning

confidence: 99%

Therapeutic Strategies for Targeting IL-33/ST2 Signalling for the Treatment of Inflammatory Diseases

Chen

Tsai

Yang

et al. 2018

Cell Physiol Biochem

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Interleukin (IL)-33, a member of the IL-1 family of cytokines, is involved in innate and adaptive immune responses via interaction with its receptor, ST2. Activation of ST2 signalling by IL-33 triggers pleiotropic immune functions in multiple ST2-expressing immune cells, including macrophages, neutrophils, eosinophils, basophils, mast cells, type 2 helper T cells, regulatory T cells, and group 2 innate lymphoid cells. IL-33-mediated effector functions contribute to the tissue inflammatory and reparative responses in various organs including lung, skin, kidney, central nerve system, cardiovascular system, and gastrointestinal system. Endogenous IL-33/ ST2 signaling exhibits diverse immune regulatory functions during progression of different diseases. IL-33 likely functions as a disease sensitizer and plays pathological roles in inflamed tissues in allergic disorders that involve hyperreactive immune responses in the context of skin and pulmonary allergy. However, IL-33 also mediates tissue-protective functions during the recovery phase following tissue injury in the central nerve system and gastrointestinal system. Modulation of the IL-33/ST2 axis, therefore, represents a promising strategy for treating immune disorders that involve dysregulation of the cytokine signalling. In the past two decades, therapeutic strategies blocking IL-33/ST2 have been extensively studied for the treatment of diseases in animal models. In this review, the current progress on the development of therapeutic biologics for targeting IL-33/ST2 signalling in inflammatory diseases is summarized.

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“…T-cell populations, cytokines, immunoglobulins, matrix metalloprotienases and eosinophils are important components in the host cellular response to infection with A. cantonensis 89 . Peng et al 90 showed that Interleukin 33 mediates type 2 immunity and is involved in causing inflammation in the CNS of mice infected with A. cantonensis. Type 2 immunity is characterized by the induction of CD4 + T helper (TH) 2 cells, which secrete cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13 causing the inflammatory response 91 .…”

Section: Pathogenesismentioning

confidence: 99%

Molecular and pathological studies on Angiostrongylus species in southeast Queensland

Aghazadeh¹

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Despite an apparent increase in cases of angiostrongyliasis in humans and animals in Australia, the epidemiology of infection with the two species of Angiostrongylus that co-exist in this country, namely A. cantonensis and A. mackerrasae, is poorly understood. This knowledge gap is particularly important with respect to Angiostrongylus mackerrasae, a species evidently native to Australia, as its ability to cause disease in humans is unknown.Likewise, there is little information on the roles of native and introduced species of rodents and molluscs as hosts of Angiostrongylus species in Australia. This thesis focuses on the gaps in the knowledge about the epidemiology of two species in southeast Queensland, highlighting the hotspots for transmission of the parasite in urban Brisbane. A comprehensive survey of rats belonging to the species Rattus rattus, Rattus norvegicus and Rattus fuscipes was conducted. The prevalence of infection with Angiostrongylus spp. was 16.5% in Rattus spp. trapped in urban Brisbane and surrounds which is much higher than estimates of earlier studies. This highlights the possible risk of zoonotic infection in children, dogs and wildlife in this region and indicates the necessity for public awareness as well as more detailed epidemiological studies on this parasite in eastern Australia.Of the two Australian species, Angiostrongylus mackerrasae appears to be adapted to life in the native bush rat, Rattus fuscipes. This species evidently has an identical life cycle to that of Angiostrongylus cantonensis. A. mackerrasae may have greater potential to infect non-rodent hosts as it has been found as adult form in the lungs, as has been recorded for an individual flying fox.This raises concerns as to the potential of this native angiostrongylid to infect domestic animals and humans. To date, data on the taxonomy, epidemiology and population genetics of A. mackerrasae are poor or unknown. Here, we describe the mitochondrial (mt) genome of A. mackerrasae with the aim of addressing some of these knowledge gaps.The complete mitochondrial (mt) genome of A. mackerrasae was amplified from a single morphologically identified adult worm, by long-PCR in two overlapping amplicons (8 kb and 10 kb). The amplicons were sequenced using the MiSeq Illumina platform and annotated using an in-house pipeline. Amino acid sequences inferred from individual protein coding genes of the mt genomes were concatenated and then subjected to phylogenetic analysis using Bayesian inference.The mt genome of A. mackerrasae is 13,640 bp in size and contains 12 protein coding genes (cox1-3, nad1-6, nad4L, atp6 and cob), and two ribosomal RNA (rRNA) and 22 transfer RNA (tRNA) genes. The mt genome of A. mackerrasae has similar characteristics to those of other Angiostrongylus species which is explained in detail in chapter 3. Phylogenic comparisons reveal III that A. mackerrasae is closely related to A. cantonensis and the two sibling species may have recently diverged compared with all other species in the genus with a highl...

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Interleukin 33 Mediates Type 2 Immunity and Inflammation in the Central Nervous System of Mice Infected With Angiostrongylus cantonensis

Cited by 32 publications

References 27 publications

Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

Therapeutic Strategies for Targeting IL-33/ST2 Signalling for the Treatment of Inflammatory Diseases

Molecular and pathological studies on Angiostrongylus species in southeast Queensland

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