Interleukin-1β gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection

Hirankarn, Nattiya; Kimkong, Ingorn; Kummee, Pittaya; Tangkijvanich, Pisit; Poovorawan, Yong

doi:10.3748/wjg.v12.i5.776

Cited by 67 publications

(50 citation statements)

References 36 publications

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“…Some studies showed that IL-1b À511 C haplotype is associated with advanced liver disease. 14,34 In the present study, genotype CC was found to be higher in asymptomatic cases, no significant difference in the proportions of CT or TT genotypes in other clinical categories was observed. Interestingly, it was observed that genotype CC category was associated with significantly lower HBV titer ( Figure 1) as well as with relatively low ALT.…”

Section: Discussioncontrasting

confidence: 67%

“…Polymorphism in the IL-1b À511 promoter region and IL-1RN gene VNTR are reported to be associated with varying degree of HBV associated clinical prognosis. 11,14 Another study from Iran found no association of IL-1RN gene polymorphism with the development of chronic HBV infection. 15 Hence the association of the above mentioned polymorphic genetic factors with HBV associated clinical outcome seems to vary from one population to another.…”

Section: W Orldwide Hepatitis B Virus (Hbv) Associatedmentioning

confidence: 99%

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Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

Biswas

Panigrahi

Pal

et al. 2013

Journal of Clinical and Experimental Hepatology

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Background: Interleukin-1b (IL-1b) is an important member of the family of the proinflammatory cytokines that modulate outcome of hepatitis B virus (HBV) infection. Objectives: This study was designed to investigate the relationship between the polymorphic genotypes of the interleukin-1b (IL-1b) promoter region and the interleukin-1 receptor antagonist gene (IL-1RN) and disease outcome in HBV-infected individuals. Methods: DNA was extracted from 395 study subjects including HBV carriers with varying clinical presentations, as well as healthy controls and spontaneously recovered cases (SRC). Polymorphisms in IL-1b (at position À511) and IL-1RN (variable nucleotide tandem repeats, VNTR) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR based assay respectively. Results: Among the study subjects, different IL-1b (at position À511) (CC, CT and TT) and IL-1RN (1/1, 1/2, 2/2 and 1/3) polymorphic genotypes were found at variable proportions. Logistic regression analysis revealed, no notable difference at the level of IL-1b promoter (P = 0.244; OR = 0.78; 95% CI = 0.52-1.18) or IL-1RN genotype polymorphism (P = 0.840; OR = 1.03; 95% CI = 0.78-1.36) among the HBV carriers and controls or SRC cases. Pairwise proportion testing showed, IL-1b À511 genotype CC was significantly higher among asymptomatic carriers (ASC) in comparison with liver cirrhosis (LC) patients (P value = 0.028) and healthy control group (P-value = 0.036). IL-1RN genotype 2/2 was considerably higher in LC group than SRC as well as control group. Combinations of IL-1b (À511) and IL-1RN polymorphisms were associated with disease progression, such as CC-1/2 with ASC and TT-2/2 with LC. Conclusion: IL-1b polymorphisms are found to be associated with disease severity. Different polymorphic combinations are associated with degree of disease severity. Overall this is the first report from Eastern India, which shows association of IL-1b polymorphisms with HBV-related hepatic complications. ( J CLIN EXP HEPATOL 2013;3:281-287)

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Section: Discussioncontrasting

confidence: 67%

Section: W Orldwide Hepatitis B Virus (Hbv) Associatedmentioning

confidence: 99%

Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

Biswas

Panigrahi

Pal

et al. 2013

Journal of Clinical and Experimental Hepatology

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“…Numerous studies have investigated the relations between cytokine polymorphisms and HCC risk; however, their results are controversial (Shin et al, 2003;Hirankarn et al, 2006;Slattery et al, 2007). Two studies have consistently noted that IL-1β-511 polymorphisms are significant risk factors for HCC progression in the Thai population and in Japanese patients (Tanaka et al, 2003;Hirankarn et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Two potentially functional SNPs (-511T/C and -1464C/G) in the promoter region of IL-1β can increase IL-1β production (Zeng et al, 2003). The promoter region of IL-1β is reportedly associated with the risk of developing cancers of the lung (Zienolddiny et al, 2004), breast (Liu et al, 2006), liver (Hirankarn et al, 2006), and stomach (El-Omar et al, 2000). IL-2 exerts pleiotropic effects on the immune system by acting as a pro-and anti-inflammatory regulator.…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Six Cytokine Gene Polymorphisms and SNP-SNP Interactions on Hepatocellular Carcinoma Risk in Southern Guangxi, China

Bei

Bai²,

Yu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-γ, IL-1β, IL-6, and IL-10) were genotyped in a study of 720 Chinese HCC cases and 784 cancer-free controls. Although none of these SNPs individually had a significant effect on the risk of HCC, we found that the combined effects of these six SNPs may contribute to HCC risk (OR=1.821, 95% CI=1.078-3.075). This risk was pronounced among smokers, drinkers, and hepatitis B virus carriers. A SNP-SNP interaction between IL-2-330 and IFN-γ-1615 was associated with an increased HCC risk (OR=1.078, 95% CI=1.022-1.136). In conclusion, combined effects of SNPs and SNP-SNP interactions in cytokine genes may contribute to HCC risk.

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“…2. High IL-6 levels are associated with a reduction in HBV replication and IL-1 is important in many inflammatory processes associated with HBV infection, including HCC (Hirankarn et al 2006, Kuo et al 2009). However, IL-1 and IL-6 levels were undetectable in the study groups.…”

Section: Analysis Of Pro-inflammatory Cytokines In Ohb-mentioning

confidence: 99%

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Fierro¹,

Román²,

Realpe³

et al. 2011

Mem. Inst. Oswaldo Cruz

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A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected patients has been poorly evaluated in vivo. Therefore, we assessed the expression profiles of 23 cytokines in OHB genotype H-infected Nahua patients. A total of 41 sera samples from natives of the Nahua community were retrospectively analysed. Based on their HBV antibody profiles, patients were stratified into two groups: OHB patients (n = 21) and patients that had recovered from HBV infection (n = 20). Herein, we report distinctive cytokines profiles in OHB-infected individuals. Compared to healthy controls (n = 20) and patients who resolved HBV infection, OHB-infected patients displayed an increase in interleukin (IL)-2 secretion in addition to a characteristic inflammation profile (decrease in IL-8 and tumour necrosis factor-alpha levels and increased levels of tumour growth factor-beta). IL-15 and interferon-gamma levels were reduced in OHB-infected individuals when compared to those patients who resolved HBV infection. In contrast, OHB patients showed an increase in monocyte chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls and patients who resolved HBV infection. These findings suggest that cytokine expression can influence the severity of OHB disease and could lead to new investigation into the treatment of liver and other infectious diseases

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Interleukin-1β gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection

Abstract: IL-1B-511C allele, which may be associated with high IL-1B production in the liver, is a genetic marker for the development of HCC in chronic hepatitis B patients in Thai population.

Cited by 67 publications

References 36 publications

Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

Combined Effects of Six Cytokine Gene Polymorphisms and SNP-SNP Interactions on Hepatocellular Carcinoma Risk in Southern Guangxi, China

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

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