Interleukin 19 reduces inflammation in chemically induced experimental colitis

Exacerbated experimental pancreatitis in interleukin-19 knockout mice

“…Recent studies have shown that IL-19 was produced by keratinocytes [3,4], epithelial cells [5][6][7][8], macrophages [9,10], B cells [11,12], and vascular smooth muscle cells [13]. Our previous studies showed that IL-19-knockout (KO) mice were more susceptible to experimental acute colitis induced by dextran sulfate sodium, TNBS, and oxazolone [10,14,15]. These results indicate that IL-19 plays as the anti-inflammatory effector.…”

“…Cerulein-induced pancreatitis is a wellcharacterized model of acute pancreatic inflammation. Cerulein is the cholecystokinin (CCK) analogue and, when it is given to the animals, the excess stimulation leads to abnormally high secretion of digestive to generate IL-19 KO mice [14]. C57BL/6-IL-19 heterozygous mice were intercrossed to generate mutant and control mice.Age-matched mice (9-12 weeks old) were used in all experiments.…”

The Role of Interleukin-19 in Contact Hypersensitivity

“…7) We previously generated IL-19 deficient (IL-19 knock out (KO)) mice that demonstrate, in vivo, the importance of inflammatory bowel disease and, in vitro, the significance of macrophage function. [8][9][10] [17][18][19] The psoriatic epidermis has high IL-19 expression, 19) and IL-19 released by keratinocytes upregulates the production of keratinocyte growth factor from CD8 + T cells, which form a positive feedback loop that exacerbates psoriasis. 18) Thus, IL-19 regulates the development of psoriasis through the facilitation of the Th1 response.…”

“…9) After 48 h, the concentration of IL-17 was determined using an enzyme-linked immunosorbent assay (ELISA).…”

Intestinal IL-17 Expression in Canine Inflammatory Bowel Disease

“…IHC of 3-μm-thick paraffin-embedded sections was performed as previously described [20], with minor modifications. We used primary antibodies against IL-17 (ab79056; Abcam, Cambridge, MA, USA).…”