Biochemical Pharmacology volume 77, issue 12, P1835-1844 2009 DOI: 10.1016/j.bcp.2009.03.008 View full text
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Jennifer H. Shin, Dong Wook Shin, Minsoo Noh

Abstract: The immune system is closely linked to human metabolic diseases. Serum levels of IL-6 increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin sensitivity of human cells such as adipocytes, but it also regulates the lineage commitment of naïve T cells into interleukin (IL)-17A-producing CD4(+) T (Th17) cells. Although IL-17A exerts a variety of effects on somatic tissues, its functional role in human adipocytes has not been identified. In this work, we show that IL-17A inhibits adi…

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