Interleukin-17A in lipid metabolism and atherosclerosis

Jiang, Na; Zheng, Xi-Long; Cayabyab, Francisco S.; Tang, Zhi-Bin; Tang, Chao-Ke

doi:10.1016/j.cca.2014.01.012

Cited by 38 publications

(40 citation statements)

References 72 publications

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“…IFN-γ is a unique member of the type II IFN. [93,94] IFN-γ is principally secreted by monocytes, macrophages, T cells, natural killer (NK) cells, dendritic cells and B lymphocytes. IFN-γ is a critical regulator of immune function and provides a robust first-line of defense against invading pathogens.…”

Section: Ifn-γmentioning

confidence: 99%

Role of neuroinflammation in ischemic stroke

Li¹,

Pan²,

Tang³

et al. 2017

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Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation occurs initially depending on activated resident microglia that has the same function as the macrophage. Activated microglia participates in the neuroinflammatory process by phagocytosing the injured brain cells and producing the pro-and anti-inflammatory mediators. In this review, the authors present an overview of the role of microglia in mediating neuroinflammation in ischemic stroke. Key words:Microglia, ischemic stroke, neuroinflammation ABSTRACT Topic: StrokeThis is an open access article distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: Ifn-γmentioning

confidence: 99%

Role of neuroinflammation in ischemic stroke

Li¹,

Pan²,

Tang³

et al. 2017

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“…The interleukin 17 (IL-17) cytokine family includes six members named A-F, in which IL-17A is the main cytokine [24]. IL-17A was initially reported to be mainly expressed by activated cluster of differentiation 4+ (CD4+) T cells [7].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Shao-ru

Liu

et al. 2014

Inflammation

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Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. In the current study, we examined two single nucleotide polymorphisms (SNPs), rs2275913G/A and rs3748067C/T, in the IL-17A gene between AMD patients and healthy controls. Results showed that rs2275913AA genotype and rs3748067TT genotype were associated with increased susceptibility to AMD (hazard ratio [HR], 1.75; 95 % confidence interval [CI], 1.07 to 3.02; P=0.023, and HR, 2.12; 95 % CI, 1.26 to 4.01; P=0.004; data were adjusted for age and sex). Next, we investigated the functional relevance of the two SNPs. In vitro stimulated peripheral blood mononuclear cells (PBMCs) from subjects possessing the rs2275913AA genotype produced significantly more IL-17 than those with the GG genotype. However, PBMCs with rs3748067TT genotype revealed significantly higher IL-17 production than those with rs3748067CC genotype only in AMD patients but not in controls. These data indicate IL-17A polymorphisms are associated with increased risk of AMD probably by affecting gene expression.

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“…However, its role is unclear, given conflicting results that have shown both protective and pathogenic effects 43,44 . In the present study, we found that Pdcd4 deficiency led to decreased production of IL-17 by T cells in vitro and a low level of IL-17 expression in CD4…”

Section: Pdcd4 Affects Atherosclerosis By Regulating Il-10 Y Jiang Et Almentioning

confidence: 99%