Interleukin-17A and Chronic Stress in Pregnant Women at 24–28 Weeks Gestation

Abstract

Background: Allostatic Load (AL) is a biopsychosocial model that suggests chronic psychosocial stress leads to physiologic dysregulation and poor outcomes. The purpose of this study was to examine AL in pregnant women operationalized using pro-inflammatory cytokines and psychosocial indicators and perinatal outcomes. Objectives: In pregnant women, identify relationships between circulating cytokines/ chemokines and the Prenatal Distress Questionnaire (PDQ), Maternal Antenatal Attachment Scale (MAAS), Emotional and Quotient Inventory (EQi), Life Experiences Scale (LES), and demographics. Methods: A cross-sectional design was used to recruit pregnant women between 24-28 weeks gestation. Blood and stress/emotional indicators were obtained after informed consent. Plasma was abstracted to simultaneously measure 29 cytokines/chemokines using a multiplex array. Cytokine/ chemokine levels were compared with continuous variables using Spearman's Rho and with categorical variables using Mann-Whitney U.

Inflammatory mediators of stress exposure and neurodevelopment in very preterm infants: Protocol for the stress neuro‐immune study

“…A panel of plasma anti‐inflammatory (interleukin [IL]‐10, IL‐4, IL‐1 receptor antagonist [RA]) and pro‐inflammatory (IL‐6, IL‐8, tumour necrosis factor‐alpha [TNF‐α], IL‐1β, IL‐17A, monocyte chemoattractant protein (MCP)‐1) cytokines and chemokines will be quantified using a custom Bio‐Plex multiplex immunoassay (Bio‐Rad; Hercules, CA), which uses Luminex xMAP technology (Luminex Corp; Austin, TX) and has been successfully used for the quantification of cytokines and chemokines in neonatal peripheral blood (Carlo et al, ; Matoba et al, ). The pro‐inflammatory cytokines and chemokines were selected for their previously demonstrated effects on the adult and infant brain (Jain & Mills, ), neurodevelopment (Kinjo et al, ; O'Shea et al, ), or association with chronic stress exposure (Moore et al, ). The anti‐inflammatory factors were selected for their regulating effects on IL‐1β, IL‐6, IL‐8, MCP‐1, and TNF‐α (Moore, de Waal Malefyt, Coffman, & O'Garra, ) and importance in higher cognitive function (Gadani, Cronk, Norris, & Kipnis, ).…”

Apego materno-fetal em gestantes de alto risco: uma revisão integrativa

“…Foram encontrados estudos dos seguintes países Turquia (n=4), Coréia do Sul (n=2), Finlândia (n=1), Chile (n=1), Estados Unidos (n=1), Inglaterra (n=1), Polônia (n=1) e Brasil (n=1), evidenciando escassez de pesquisas no território nacional. & Güneri, 2020;Mackie et al , 2020;Moore et al, 2019;Souza et al, 2022;Topan et al, 2022), dois tiveram como objetivo verificar a capacidade preditiva de determinados fatores na intensidade do AMF (Kucharska, 2020;Yoon & Sung, 2021), três compararam grupos de gestantes de alto e baixo risco (Dagla et al, 2022;Palma et al, 2020;Yesilcinar et al, 2023) promoção do AMF (Baltacı & Başer, 2022;Jussila et al, 2021;Kim & Chun, 2020).…”

Postnatal Cytokine Trajectories in Very Preterm Infants

“…After enrollment, blood samples for the quantification of cytokines were collected weekly until infants reached 35 weeks PMA. We selected cytokines for the parent study based on their reported associations with neurodevelopment in preterm infants (Nist & Pickler, 2019), stress (Moore et al, 2019), or brain development (Gadani et al, 2012).…”