1996
DOI: 10.1001/archderm.132.9.1133
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Interleukin-10 is a predominant cytokine in atopic dermatitis

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Cited by 16 publications
(9 citation statements)
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“…The decreased percentage of CD8+/TNF‐α+ T cells in the blood of patients with AD may reflect a general skewing of the immune response in patients with AD away from a Th1 and toward a Th2‐type response in the peripheral blood of patients with AD. As type 2 cytokines such as IL‐4 8,9 , 11,12 and IL‐10 22 are raised in the peripheral blood of patients with AD and these cytokines are known to suppress the monocyte secretion of TNF‐α, 23 it is possible that increased levels of IL‐4 and IL‐10 in the peripheral blood of patients with AD may contribute to the decreased percentages of CD8+/TNF‐α+ cells observed in the blood of patients with AD in this study. Further studies will examine this possibility and will also examine coexpression of Th1 and Th2 cytokines within the same T cells.…”
Section: Discussionmentioning
confidence: 77%
“…The decreased percentage of CD8+/TNF‐α+ T cells in the blood of patients with AD may reflect a general skewing of the immune response in patients with AD away from a Th1 and toward a Th2‐type response in the peripheral blood of patients with AD. As type 2 cytokines such as IL‐4 8,9 , 11,12 and IL‐10 22 are raised in the peripheral blood of patients with AD and these cytokines are known to suppress the monocyte secretion of TNF‐α, 23 it is possible that increased levels of IL‐4 and IL‐10 in the peripheral blood of patients with AD may contribute to the decreased percentages of CD8+/TNF‐α+ cells observed in the blood of patients with AD in this study. Further studies will examine this possibility and will also examine coexpression of Th1 and Th2 cytokines within the same T cells.…”
Section: Discussionmentioning
confidence: 77%
“…IL-10, IL-12, and PGE 2 . IL-10 inhibits IFN-g production by Th 1 cells (19), and IL-10 overexpression was found not only in AD skin lesions, but also in PBMC of AD patients stimulated with a nonspecific mitogen (20). Ohmen et al (15) also reported that they found overexpression of IL-10 mRNA mainly in CD14 π cells from AD lesions.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to these findings, other studies have shown either elevated IL-10 levels in PBMC’s isolated from AD patients [148], in lesional skin [149–151], or increased induction of IL-10 in PHA stimulated blood cultures from subjects with AD [152] or PBMC’s [148] and monocytes [151] stimulated with LPS. Elevated numbers of CD4+ and CD8+ cells expressing IL-10 were also observed in patients with AD [79].…”
Section: Th2 Cytokinesmentioning
confidence: 98%