volume 5, issue 10, Pe13384 2010
DOI: 10.1371/journal.pone.0013384
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Abstract: BackgroundImmunological and clinical outcomes can vary considerably at the individual and population levels during both treated and untreated HIV-1 infection. Cytokines encoded by the interleukin-10 gene (IL10) family have broad immunomodulatory function in viral persistence, and several SNPs in the IL10 promoter sequence have been reported to influence pathogenesis or acquisition of HIV-1 infection.Methodology/Principal FindingsWe examined 104 informative SNPs in IL10, IL19, IL20, IL24, IL10RA and IL10RB amon…

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