Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

Cyktor, Joshua C.; Turner, Joanne

doi:10.1128/iai.00047-11

Cited by 171 publications

(126 citation statements)

References 138 publications

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“…IL10 is essential for the modulation of the immune response, and deficiencies in IL10 can lead to tissue damage (Cyktor & Turner 2011). In addition, the IL1 system is involved with both pathologic states as well as normal reproductive function (Takehara et al 1994, Van der Hoek et al 1998, Martoriati et al 2003, Gerard et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Woodward¹,

Christoffersen²,

Campos³

et al. 2013

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Transient endometritis after breeding is necessary for clearance of bacteria and spermatozoa; however, in a subpopulation of mares, the inflammation fails to resolve in a timely fashion. The objective of this study was to describe the uterine inflammatory response in mares susceptible or resistant to persistent breeding-induced endometritis (PBIE) during the first 24 h after induction of uterine inflammation. Twelve mares were classified as susceptible (nZ6) or resistant (nZ6) to PBIE. Mares were inseminated over five estrous cycles and endometrial biopsies were collected at one time point per cycle before (0) and 2, 6, 12, and 24 h after insemination. qPCR analysis for IL1B, IL6, IL8, IFNG, TNF (TNFA), IL10, and IL1RN was performed, and endometrial inflammatory cells were counted for each sample. Relative quantification values reported fold changes in mRNA expression from 0 h values. A general pattern of expression post insemination was observed in both groups of mares. Cytokine mRNA increased at 2 h, peaked between 2 and 12 h, and then decreased. Differences were detected between groups of mares 6 h after challenge; resistant mares had higher mRNA expression of IL6, IL1RN, and IL10 than susceptible mares. Susceptible mares had an increased number of polymorphonuclear neutrophils in the endometrium 2 and 12 h after breeding when compared with resistant mares. These findings describe an inherent difference in the initial immune response to insemination and may help explain the transient nature of inflammation in resistant mares, whereas susceptible mares develop a persistent inflammation.

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Section: Discussionmentioning

confidence: 99%

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Woodward¹,

Christoffersen²,

Campos³

et al. 2013

Reproduction

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“…[14][15][16] In some cases, lack of IL-10 promotes a better microbial clearance and better survival rates, 29 although in others the lack of IL-10 leads to higher mortality due to uncontrolled inflammation with no effect in bacterial clearance. 20 Here we demonstrate that pneumococcal pneumonia infection induces the production of IL-10 in lungs, which is necessary to control inflammation, neutrophil infiltration and migration, tissue damage and host survival when mice are infected with a high dose of bacteria (3 9 10 7 CFU).…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16] It reduces inflammation by inhibiting the action of natural killer cells, the differentiation of naive T cells into effector T cells, and the secretion of pro-inflammatory cytokines, such as tumour necrosis factor-a (TNF-a) by macrophages, dendritic cells and neutrophils. 15,16 IL-10 also stimulates the proliferation of regulatory T cells, contributing to a balanced immune response consisting of pathogen clearance without excessive inflammation or damage to self tissues. 16 The contribution of IL-10 to the immune response during respiratory infections has been evaluated on different models with varying results.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 IL-10 also stimulates the proliferation of regulatory T cells, contributing to a balanced immune response consisting of pathogen clearance without excessive inflammation or damage to self tissues. 16 The contribution of IL-10 to the immune response during respiratory infections has been evaluated on different models with varying results. For instance, during Klebsiella pneumoniae infection in mice, IL-10 neutralization led to improved bacterial clearance and higher survival rates, 17 suggesting that the presence of IL-10 could be detrimental for host defense.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin‐10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae

et al. 2015

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Summary Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well as otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation of lungs due to S. pneumoniae infection promotes bacterial dissemination and severe disease. However, the contribution of anti‐inflammatory molecules to the pathogenesis of S. pneumoniae remains unknown. To elucidate whether the production of the anti‐inflammatory cytokine interleukin‐10 (IL‐10) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed S. pneumoniae infections in mice lacking IL‐10 (IL‐10−/− mice). The IL‐10−/− mice showed increased mortality, higher expression of pro‐inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after S. pneumoniae infection. However, IL‐10−/− mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL‐10 during S. pneumoniae infection modulates the expression of pro‐inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL‐10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.

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“…1). 18 The strength of either response may be dialed up by TLR signaling, inclusive of TLR4 and TLR2, 19 which would suggest that different TLR signaling pathways contribute to dissimilar biological responses upon fungal infection. A. conidia can also induce NF-kB translocation in both the TLR2 and TLR4 signaling cascades.…”

Section: Innate Immunity and Fungal Infectionmentioning

confidence: 99%

Immunity against Fungal Infections

Jiang

2016

Immunol Immunogenet Insights

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Fungal diseases are major causes of morbidity and mortality among the immunocompromised, including HIV-infected individuals and patients with cancer. Individuals without a weakened immune system can also suffer from these infections. Not surprisingly, fungi are a major target for the immune system, rendered visible to it by expression of pathogen-associated molecular patterns/signatures. We now appreciate the roles of both innate and adaptive immunity in eliminating fungal infections, and how a disproportionate or inadequate immune response can diminish the host's capacity to eliminate fungi. This review focuses on our current understanding of the roles of innate and adaptive immunity in clearing common and emergent fungal pathogens. A clearer understanding of how the host's immune response tackles fungal infection may provide useful clues as to how we might develop new agents to treat those diseases in the future.

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Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

Cited by 171 publications

References 138 publications

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis

Interleukin‐10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae

Immunity against Fungal Infections

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