T he metallic state of high-temperature copper-oxide superconductors, characterized by unusual and distinct temperature dependences in the transport properties 1-4 , is markedly different from that of textbook metals. Despite intense theoretical efforts 5-11 , our limited understanding is impaired by our inability to determine experimentally the temperature and momentum dependence of the transport scattering rate. Here, we use a powerful magnetotransport probe to show that the resistivity and the Hall coefficient in highly doped Tl 2 Ba 2 CuO 6+δ originate from two distinct inelastic scattering channels. One channel is due to conventional electronelectron scattering; the other is highly anisotropic, has the same symmetry as the superconducting gap and a magnitude that grows approximately linearly with temperature. The observed form and anisotropy place tight constraints on theories of the metallic state. Moreover, in heavily doped non-superconducting La 2−x Sr x CuO 4 , this anisotropic scattering term is absent 12 , suggesting an intimate connection between the origin of this scattering and superconductivity itself.The in-plane properties of layered metals can sometimes be obtained from measurements of out-of-plane quantities. For example, angular magnetoresistance oscillations (AMRO), which are angular variations in the interlayer resistivity ρ ⊥ induced by rotating a magnetic field H in a polar plane relative to the conducting layers, can provide detailed information on the shape of the in-plane Fermi surface (FS) in layered metals. Here we resolve for the first time, the momentum (k) and energy (ω or T) dependence of the in-plane transport lifetime τ in an overdoped cuprate Tl 2 Ba 2 (Ca 0 )Cu 1 O 6+δ (Tl2201) through advances, both experimental and theoretical, in the AMRO technique. Experimentally, we extend the temperature range of previous AMRO measurements on overdoped Tl2201 13 (with a superconducting transition temperature T c = 15 K) by more than one order of magnitude. Theoretically, we derive a new general analytical expression for the interlayer conductivity σ ⊥ in a tilted H that incorporates basal-plane anisotropy. For T > 4 K, the AMRO can only be explained by inclusion of an anisotropic scattering rate 1/τ whose anisotropy grows with T. Significantly, the anisotropy in 1/τ and its T dependence up to 55 K can quantitatively account for both the robust linear-in-T component to the in-plane resistivity ρ ab and the T-dependent Hall coefficient R H over the same temperature range 14,15 . These anomalous behaviours are not characteristic of a simple Fermi liquid, which is often the starting point for modelling overdoped cuprates. We discuss the consequences of these findings for our understanding of the normal-state transport in cuprates.As described in the Supplementary Information, detailed azimuthal and polar-angle-dependent AMRO data were taken at 4.2 K and 45 T and fitted to the Shockley-Chambers tube integral form of the Boltzmann transport equation, modified for a quasitwo-dimensional (quasi...