Interhemispheric Balance in Parkinson's Disease: A Transcranial Magnetic Stimulation Study

Spagnolo, Fabio; Coppi, Elisabetta; Chieffo, Raffaella; Straffi, L.; Fichera, Mario; Nuara, Arturo; González-Rosa, Javier J.; Martinelli, Vittorio; Comi, Giancarlo; Volontè, Maria Antonietta; Leocani, Letizia

doi:10.1016/j.brs.2013.05.004

Cited by 46 publications

(39 citation statements)

References 27 publications

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“…Compensatory mechanisms that have been described are: expansion of activated cortical areas, increased excitability of cortical areas, and involvement of contralateral hemisphere (Kojovic et al, 2012;Spagnolo et al, 2013). This compensatory reorganisation can influence the interhemispheric balance (Spagnolo et al, 2013). In motor tasks, the lateralized dopamine deficits are compensated by expanding the normal motor network to areas that are usually only activated in complex movements and/or by increasing the excitability of motor areas.…”

Section: Introductionmentioning

confidence: 97%

“…The brain tries to mitigate the dopamine deficiencies with compensatory neural responses. Compensatory mechanisms that have been described are: expansion of activated cortical areas, increased excitability of cortical areas, and involvement of contralateral hemisphere (Kojovic et al, 2012;Spagnolo et al, 2013). This compensatory reorganisation can influence the interhemispheric balance (Spagnolo et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

“…In early PD, this increased excitability is only present in the most affected hemisphere, creating an imbalance between both hemispheres. As PD advances, this imbalance disappears, due to an increased excitability of both hemispheres (Spagnolo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

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Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

et al. 2015

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“…TMS paradigms have been applied in the study of a variety of neurological diseases including epilepsy (Badawy et al, 2007;Badawy et al, 2009;Macdonell et al, 2002), motor neurone disease (Vucic et al, 2013), dementia (Cantone et al, 2014), migraine (Afra et al, 1998), Parkinson's disease (Spagnolo et al, 2013) and stroke as well as MS. The existing literature regarding the application of single-and paired-pulse TMS paradigms to MS patients will now be reviewed.…”

Section: Applications Of Tms Paradigms To Ms Patientsmentioning

confidence: 99%

The use of transcranial magnetic stimulation in diagnosis, prognostication and treatment evaluation in multiple sclerosis

Simpson

Macdonell

2015

Multiple Sclerosis and Related Disorders

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“…TCI was assessed as the ipsilateral silent period (iSP) duration from each FDI, using a TMS intensity of 80 % maximum stimulator output (MSO), similar to previous studies (Chen et al , 2003, Trompetto et al , 2004, Stinear et al , 2008, Spagnolo et al , 2013, Stinear et al , 2015. Participants were instructed to produce an isometric contraction of the FDI muscle of one hand at approximately 75 % of their maximal effort, while 20 single pulse stimuli were delivered to the ipsilateral M1.…”

Section: Transcallosal Inhibitionmentioning

confidence: 99%

P244 The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke

Fleming

Rothwell

Sztriha

et al. 2017

Clinical Neurophysiology

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. (2017). P244 The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke. CLINICAL NEUROPHYSIOLOGY, 128(3), e133. DOI: 10.1016DOI: 10. /j.clinph.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policyIf you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Improvement in the Jebsen Taylor Test was seen after unilateral motor cortex tDCS but not after bihemispheric motor cortex tDCS. Changes in performance with tDCS were independent of changes in transcallosal inhibition. AbstractObjective: To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements.Methods: 24 stroke survivors (3-124 months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham. The Jebsen Taylor hand function test (JTT) was assessed pre-and poststimulation and TCI assessed as the ipsilateral silent period (iSP) duration using transcranial magnetic stimulation. Results:The time to react to target illumination reduced with learning of the movement se...

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Interhemispheric Balance in Parkinson's Disease: A Transcranial Magnetic Stimulation Study

Cited by 46 publications

References 27 publications

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

Subthalamic nucleus stimulation and spontaneous language production in Parkinson’s disease: A double laterality problem

The use of transcranial magnetic stimulation in diagnosis, prognostication and treatment evaluation in multiple sclerosis

P244 The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke

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