Interferon lambda in inflammation and autoimmune rheumatic diseases

COVID-19 outcomes in patients with Dermatomyositis: A registry-based cohort analysis

“…The risk of VTE is already high in the COVID-19 infection alone, but with the added disease of DM, the risk is greater than in the general population. 31 , 32 We found an accentuated risk of VTE in the matched subset with ILD, which may be contributed by immobility due to the lung condition. The contribution of VTE in most autoimmune rheumatic diseases is because of chronic inflammation and/or the presence of the antiphospholipid syndrome (APLs).…”

Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner

“…Although a function for neutrophils at the maternal-fetal interface has not been well defined, mouse neutrophils do respond to IFN-λ. However, IFN-λ has anti-inflammatory activity in these contexts and is associated with reductions in inflammatory pathology during influenza infection as well as rheumatoid arthritis ( 45 , 46 ). Further research focusing on identifying the specific maternal cell types that respond to IFN-λ signaling will enhance our understanding of the mechanisms underlying IFN-λ-mediated fetal pathology.…”

Interferon Lambda Regulates Cellular and Humoral Immunity in Pristane-Induced Lupus

“…The more recently discovered members of the interferon family, namely type III interferons (IFN-λ), were initially described to play a role in the defense against viral pathogens on barrier surfaces [ 24 , 46 , 47 ]. However, there is growing evidence that IFN-λ also contributes to inflammation in autoimmune disorders [ 48 ]. This includes findings of increased concentrations of type III IFN in the sera of patients with SLE, which correlated with disease activity [ 25 , 26 , 27 , 28 , 29 ].…”