Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Gibellini, Lara; Pinti, Marcello; Nasi, Milena; Biasi, Sara De; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea

doi:10.3390/cancers2021288

Cited by 207 publications

(148 citation statements)

References 151 publications

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“…The effect of growth factor signalling may not be significant in our cells, as Cook et al [4] observed no change in anti-oestrogen resistance when cell surface signalling was To model LCC9 cells, we assumed a higher basal rate of unfolded protein production than in LCC1 cells. Persistent ROS stress or persistent production of unfolded proteins may induce adaptive stress responses, enabling cells to maintain viability [89]. Since LCC9 cells were obtained from LCC1 cells by a stepwise selection using ICI, we speculate that LCC9 cells are adapted to survive higher stress levels than their parental LCC1 cells.…”

Section: Discussionmentioning

confidence: 95%

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

et al. 2013

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One contribution of 11 to a Theme Issue 'Integrated cancer biology models'. Understanding the origins of resistance to anti-oestrogen drugs is of critical importance to many breast cancer patients. Recent experiments show that knockdown of GRP78, a key gene in the unfolded protein response (UPR), can re-sensitize resistant cells to anti-oestrogens, and overexpression of GRP78 in sensitive cells can cause them to become resistant. These results appear to arise from the operation and interaction of three cellular systems: the UPR, autophagy and apoptosis. To determine whether our current mechanistic understanding of these systems is sufficient to explain the experimental results, we built a mathematical model of the three systems and their interactions. We show that the model is capable of reproducing previously published experimental results and some new data gathered specifically for this paper. The model provides us with a tool to better understand the interactions that bring about anti-oestrogen resistance and the effects of GRP78 on both sensitive and resistant breast cancer cells.

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Section: Discussionmentioning

confidence: 95%

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

et al. 2013

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“…A number of studies have demonstrated that quercetin exhibits a variety of pharmacological effects, including antioxidant and anti-cancer activities [68,69], while some reports relate to effectiveness in controlling melanogenesis. Quercetin is recognized as a potent inhibitor of tyrosinase activity and melanogenesis, as evidenced by the studies performed in the mouse B16 melanoma cells [70].…”

Section: Synthesis Of Quercetin Derivatives and The Melanogenesis Stimentioning

confidence: 99%

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Mitsunaga

Yamauchi

2015

J Wood Sci

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Controlling melanogenesis is important for maintaining the good health and cosmetic appearance of a human body. This study aims to search the active compounds from natural products exhibiting the melanogenesis modulating activity and elucidate the mechanism underlying the observed activity. Two novel quercetin glycosideswere isolated and identified from Helminthostachys zeylanica roots 50 % ethanol extract. Compound 1 exhibited intracellular melanogenesis stimulatory activity, while 2 showed no effect even the structural similarity. To understand the structure-activity relationships, twelve quercetin glycosides and seven methylquercetins were synthesized from rutin as starting material. As the result of bioassay using synthesized nineteen quercetin derivatives in B16 melanoma cells, some quercetin-3-O-b-D-glucopyranosides stimulated the intracellular melanogenesis. On the other hand, synthesized 3-O-methylquercetin 12 and 3,4 0 ,7-Otrimethylquercetin 15 increased both intra and extracellular melanin contents with no cytotoxicity. Compoud 15 increased the phosphorylated p38 mitogen-activated protein kinase (MAPK) and microphthalmia-associated transcription factor (MITF) which regulates the expression of tyrosinase, TRP-1 and TRP-2. While 12 enhanced the expression of the melanogenic enzymes without involving the MITF, as evidenced by its lack of any stimulation of the expression of MITF and p-p38 MAPK. This result indicates that 12 may stimulate the expression of tyrosinase, TRP-1, and TRP-2 by stimulating currently unidentified transcriptional factors and/or by regulating the degradation of melanogenic enzymes.

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“…Ascorbic acid is oxidised by ROS produced by these neoplastic cells [32]. In this study there was an increased rate of ascorbic acid degradation in the EBC of patients with lung cancer compared with healthy control subjects.…”

Section: Discussionmentioning

confidence: 47%

Tumour Necrosis Factor Alpha and Oxidative Stress in the Breath Condensate of Those with Non-Small Cell Lung Cancer

Chan¹,

Sivagnanam²,

Zhang³

et al. 2012

JCT

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Background and Aims: Lung cancer is a leading cause of cancer mortality worldwide and is associated with the release of tumour necrosis factor-α (TNF-α), subsequent cellular apoptosis and the generation of oxidative stress. Exhaled breath condensate (EBC) analysis is a non-invasive method for sampling biofluids from the lower respiratory tract. This study aimed to evaluate possible biomarkers of lung cancer by measuring the levels of TNF-α and the oxidation of ascorbic acid in EBC. Patients with lung cancer were enrolled into the study prior to treatment, during treatment and post-treatment, and results compared with an age-matched control population. Material and Methods: Patients with Stages II-IV non small cell lung cancer (NSCLC) were recruited prior to and at stages of their treatment. EBC levels of TNF-α, and rate of ascorbic acid oxidation were measured. Results: A total of 19 patients with NSCLC (mean age 71.37 ± 7.77 yr) and 25 age-matched control subjects were enrolled. Levels of EBC TNF-α were elevated in the EBC of patients with lung cancer compared with control subjects (1.02 ± 0.07 pg/ml vs 0.51 ± 0.06 pg/ml, p < 0.0001). Moreover, the rate of ascorbic acid oxidation was significantly greater in the EBC of patients with lung cancer compared with control subjects (2.20% [0.4 -11.0] vs 1.00% [0.1 -8.5], p = 0.0244). Conclusion: TNF-α and the rate of ascorbic acid oxidation was elevated in the EBC of patients with lung cancer regardless of treatment. Longitudinal studies in a larger population are required to evaluate these markers for the effect of treatment and prognosis.

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Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Cited by 207 publications

References 151 publications

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

Effect of quercetin derivatives on melanogenesis stimulation of melanoma cells

Tumour Necrosis Factor Alpha and Oxidative Stress in the Breath Condensate of Those with Non-Small Cell Lung Cancer

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