Interference by Aerobic and Anaerobic Bacteria in Children With Recurrent Group A β-Hemolytic Streptococcal Tonsillitis

Abstract

The tonsils of children with a history of recurrent GABHS infection contain fewer aerobic and anaerobic bacteria with interfering capability of GABHS than those without the history of recurrent GABHS infection. The presence of these interfering bacteria may play a role in preventing GABHS infection.

Respiratory microorganisms in acute pharyngitis patients: Identification, antibiotic prescription patterns and appropriateness, and antibiotic resistance in private primary care, central Malaysia

“…According to Crowe et al [ 57 ], a few organisms in throat microflora were found to interfere with colonization of GABHS by exhibiting bactericidal activity, among these organisms were viridans streptococci and Neisseria spp. A few other studies proved similar [ 58 , 59 ]; interfering capability of viridans streptococci was especially apparent in Sanders [ 60 ]’s study where viridans Streptococci was the sole microorganism that antagonized growth of GABHS among four indigenous organisms studied ( Streptococcus spp. viridans group, Staphylococcus epidermis , Diphtheroids and non-pathogenic Neisseria ).…”

Application of an enzyme‐labeled antigen method for visualizing plasma cells producing antibodies against Strep A, a carbohydrate antigen of Streptococcus pyogenes, in recurrent tonsillitis

“…Normal flora inhibits replication of S. pyogenes by competing for nutrients, whereas excessive prescribing of antibacterial drugs leads to killing of the normal flora on the throat, which increases susceptibility to S. pyogenes infection (8,29). Reportedly, the normal flora is significantly suppressed in S. pyogenes-infected tonsils (30). Sequence analysis of the 5 0 end of the amplified emm gene encoding M protein of S. pyogenes showed that nine lesions (75%) were caused by type emm12 and three (25%) by type emm1.…”

“…Normal flora inhibits replication of S. pyogenes by competing for nutrients, whereas excessive prescribing of antibacterial drugs leads to killing of the normal flora on the throat, which increases susceptibility to S. pyogenes infection . Reportedly, the normal flora is significantly suppressed in S. pyogenes ‐infected tonsils .…”

Scavenger receptor gp340 aggregates group A streptococci by binding pili

“…, 1991). Although little is known about the role of indigenous bacteria in GAS colonization, there is some evidence that commensal streptococci reduce phayngeal colonization by S. pyogenes , while β‐lactamase‐producing anaerobes protect GAS from penicillin (Brook and Gober, 1995; 1999; Nobbs et al. , 2007).…”