Interface dermatitis. How specific are its histopathologic features?

LeBoit, Philip E.

doi:10.1001/archderm.129.10.1324

Cited by 29 publications

(45 citation statements)

References 10 publications

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“…3 cases of SLE and 8 cases of DLE showed follicular plugging, perivascular lymphocytic infiltrate in the papillary dermis and extravasation of RBCs. Le Boit et al 1 reported that lymphocytic infiltrate in DLE is accompanied by fibrin thrombi within the vessel lumina, which was not seen in our cases.3 cases of SLE and 6 cases of DLE had periappendageal inflammatory infiltrate. Colloid bodies were seen in 3 cases of DLE.…”

Section: Discussioncontrasting

confidence: 49%

“…Le Boit et al has reported perivasular lymphocytes around the superficial plexus in early lesions and subepidermal vesiculation due to confluence of clefts at dermoepidermal junction. 1 All cases of BP showed spongiosis of epidermis with focal basal cell vacuolation. Lower epidermis & papillary dermis showed eosinophilic infiltration similar to study by Lever et al 8 All cases of SLE and DLE showed hyperkeratosis & atrophy of epidermis.…”

Section: Discussionmentioning

confidence: 97%

“…They have been reported by Lever et al 8 . Le Boit et al 1 have reported that colloid bodies in DLE are evidence of damage to basal cell layer.…”

Section: Discussionmentioning

confidence: 99%

“…Criteria now exist for the microscopic diagnosis of many inflammatory skin diseases and this has increased the utility of biopsy procedures in inflammatory conditions. 1 Interface dermatitis is defined as an inflammatory skin disease in which the junction between the papillary dermis and the epidermis is obscured. They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermoepidermal junction.…”

Section: Introductionmentioning

confidence: 99%

“…They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermoepidermal junction. 1 The lymphocytes infiltrate the basal layer of the epidermis and cause cytotoxic damage to or kill the keratinocytes by induction of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

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A Study of Interface Dermatitis With Clinical Correlation

Kumar¹,

Nandakumar²

2015

jemds

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BACKGROUND:Interface dermatitis (ID) is defined as an inflammatory skin disease in which the junction between the papillary dermis and the epidermis is obscured. They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermo-epidermal junction. Interface dermatitis encompasses multiple clinical entities with diverse histological features. This study is aimed at understanding the various associated histological features with clinical correlation of conditions in which Interface Dermatitis is the most important histopathologic finding. This will help us in arriving at a more specific diagnosis by light microscopy. MATERIALS AND METHODS:The study was conducted over a period of two and a half years. Skin biopsies showing interface dermatitis as a major histological finding were studied in detail and classified according to Le Boit's classification. PAS staining was done to highlight pathology of basement membrane. Normal skin biopsies & biopsies with an unrelated condition were taken as control. Correlation between clinical features, clinical diagnosis and histological diagnosis was assessed. RESULTS: 71 cases showing interface dermatitis were studied. The most common age range was between 50-59 years with a female preponderance. Majority of the cases belonged to type I interface dermatitis with lichen planus being representative of this type. PAS staining revealed basement membrane disruption in many of the cases. CONCLUSION: Interface dermatitis includes diverse entities which have overlapping features at the clinical and histopathological level. Hence, a detailed light microscopic examination aided further by special tests such as immunofluorescence will help at arriving at a definitive diagnosis. More studies are also needed in order to identify specific features to redefine each of the entities.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 97%

“…They have been reported by Lever et al 8 . Le Boit et al 1 have reported that colloid bodies in DLE are evidence of damage to basal cell layer.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%