Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex

Cobalt Complexes as Antiviral and Antibacterial Agents

“…Complexes containing a sulfur atom as part of a ligand donor set represent the largest class of cobalt(III) compounds studied for their antibacterial properties [33,34,35,36,37,38,39]. Sharma and coworkers synthesized octahedral Co(III) complexes 22a–e containing tridentate N, N, S thiosemicarbazone ligands (Figure 13) [35].…”

“…In addition to being widely used in the treatment of peptic ulcers and reflux esophagitis, famotidine has also been used in the treatment of Zollinger-Ellison syndrome, Parkinson's disease and Alzheimer's disease. In 2006, Miodragović described the coordination of famotidine to cobalt(III) and reported the isolation of complex 26 (Figure 14) [36]. The octahedral geometry and tetradentate ligand coordination was confirmed using X-ray crystallography in which extensive intermolecular hydrogen bonding and non-covalent CH•••π and NH•••π interactions, as well as π-stacking interactions were observed.…”

Hydrothermal synthesis of zeolite composite membranes and crystals as potential vectors for drug-delivering biomaterials

“…Thus, both species could exists and the drug adsorption percentage reveals a minimum value for all sample, in this range of pH range, because the electrostatic interactions with zeolite materials decrease. In solution phase, famotidine is an efficient chelating agent for different transition metals, and its complexes with Cu(II) [40][41][42][43][44], Ni(II) [40,[45][46][47] and Co(III) [48] have been recently synthesized and characterized. It offers various potential coordination sites such as the guanidine, thiazole nitrogen, thioether sulphur and amine group nitrogen, but the peculiarities of the transition metal ions as well as the experimental conditions used can influence the type of drug coordination.…”

Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

“…Furthermore, cobalt complexes possess in vivo insulin-like properties [7, 8], anti-fungal and anti-oxidant activities [9]. Several Co(III) complexes with anti-microbial activities have been reported [10–14]. For instance, a Co(III) complex of the known anti-ulcer drug famotidine turned out to have greater anti-microbial activity against M. lysodeikticus and Escherichia coli than the metal free drug [10–14].…”