Interest of the association retinaldehyde/glycolic acid in adult acne

Dréno, Brigitte; Castell, Anne-Laure; Tsankov, Nikolaï; Lipozenčić, Jasna; Serdaroglu, S.; Gutierrez, V.; Gadroy, A; Mérial-Kieny, C.; Méry, Sophie

doi:10.1111/j.1468-3083.2009.03099.x

Cited by 19 publications

(31 citation statements)

References 20 publications

(40 reference statements)

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“…It seems clear that there is an emerging population of individuals seeking acne treatment who are aged 25 and older with acne that is generally similar to that of adolescent acne. These are often active patients, experiencing a relatively high level of daily stress; based on adult subgroup analyses of large‐scale controlled clinical trials of various acne medications and other studies, it seems likely that these individuals will respond well to conventional acne therapy . The majority of adult women who have acne lesions report continuing or relapsing acne from adolescence, and they have often used many topical and/or systemic products.…”

Section: Discussionmentioning

confidence: 99%

Large‐scale international study enhances understanding of an emerging acne population: adult females

Dréno

Thiboutot

Layton

et al. 2014

Acad Dermatol Venereol

113

106

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This study represents the first objective assessment of the facial distribution of acne lesions in adult women presenting to the dermatology office. The data surprisingly indicate that the acne distribution in almost 90% of cases is similar to that seen in adolescent acne. The stereotype of adult female acne being due to hormonal disturbances presenting as inflammatory acne localized only to the mandibular area was not found in the majority of this large group. The large majority (93.7%) of women had facial comedones. We recommend that the general treatment approach for adult acne should include agents that target each of the acne lesion subtypes. Subgroup analyses of recent large-scale controlled clinical trials have shown that many adult women respond well to standard first-line acne therapy.

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Section: Discussionmentioning

confidence: 99%

Large‐scale international study enhances understanding of an emerging acne population: adult females

Dréno

Thiboutot

Layton

et al. 2014

Acad Dermatol Venereol

113

106

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“…Since low concentrations of AHA (5–10%) act on the superficial layers of the skin – by augmenting the healing response by subcorneal epidermolysis, opening comedones and unroofing pustules – many dermatologists feel that products containing AHAs should not be classified as cosmetics . However, several studies (including a large multicentre, double‐blind, randomized, vehicle‐controlled trial) have demonstrated the safety and efficacy of a preparation containing a combination of the AHA glycolic acid and retinaldehyde (a form of vitamin A) in treating acne and post‐inflammatory hyperpigmentation associated with acne . Furthermore, a recent single‐centre, double‐blind, randomized, placebo‐controlled trial on 10% glycolic acid monotherapy for mild acne showed significant improvement in acne compared with the placebo after 90 days of treatment …”

Section: Alpha‐hydroxy Acidsmentioning

confidence: 99%

The role of topical dermocosmetics in acne vulgaris

Araviiskaia

Dréno²

2016

Acad Dermatol Venereol

106

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Acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. The role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. Dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. Therefore, it has become important for dermatologists to understand dermocosmetics to effectively and appropriately advise patients on their use. The objective of this review was to provide new insights into the role of traditional and novel ingredients in dermocosmetics for the treatment of acne, based on the authors' objective assessment of the published literature. The type of products discussed include: those which have a sebostatic effect, such as topical antioxidants and niacinamide; agents targeting abnormal keratinization, such as salicylic acid, lipo-hydroxy acid, alpha-hydroxy acids, retinol-based products and linoleic acid; agents targeting Propionibacterium acnes, such as lauric acid; and anti-inflammatory agents such as nicotinamide, alpha-linolenic acid and zinc salts. Despite the scientific advances in understanding these cosmetic ingredients, there still remains a lack of rigorous controlled studies in this area.

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“…However, in a second study there were no significant differences in effectiveness between GA and SA. 14,15 …”

Section: Resultsmentioning

confidence: 99%

“…15 Although a slight redness and swelling might be seen after treatment with GA and it's especially happens in black-skinned patients. 5,17 GA is an alpha-hydroxyl acid and works by removing the corneum stratum layer, scattering basal melanocytic layer and stimulating epidermolysis.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris

Al-Talib

Al-Khateeb

Hameed

et al. 2017

An. Bras. Dermatol.

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Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid

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Interest of the association retinaldehyde/glycolic acid in adult acne

Abstract: These data show that a combination of RAL 0.1% and GA 6% may be used in association with other topical anti-acne treatments with an excellent tolerance.

Cited by 19 publications

References 20 publications

Large‐scale international study enhances understanding of an emerging acne population: adult females

Large‐scale international study enhances understanding of an emerging acne population: adult females

The role of topical dermocosmetics in acne vulgaris

Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris

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