Interdigitating Dendritic Cell Sarcoma of the Eyelid With a Rapidly Fatal Course

Abstract

exceptional cases seem to indicate that something in addition to a mechanical, tractional relationship participates in macular hole formation, at least in some instances. The OCT images in the case reported here depict this apparently tractionless sequence more clearly than previously described. An alternative explanation is that the traction component is below the resolution of OCT. A possible mediator might be the outer wall of vitreoschisis as has been proposed by Sebag, 5 and this may be depicted on the left side of Figure 2A and B as focal areas of minimal separation of what might alternatively be interpreted as the internal limiting membrane. Degenerative factors such as subtle defects or breaks in the internal limiting membrane (tractionally or senescently induced) may allow hydration of the fovea and distort tissue enough to form a full-thickness macular hole. 6 This may explain why surgical removal of vitreofoveal traction does not uniformly prevent macular hole formation. The mechanisms of macular hole formation are still incompletely understood but may involve degenerative and tractional factors. A full understanding of pathogenetic mechanisms would likely optimize treatment and prevention of full-thickness macular holes.

Primary Cutaneous Interdigitating Dendritic Cell Sarcoma

“…After the second surgery, no further recurrence was identified at 1 year follow-up visit. In the other case reported by Boldin et al, 4 after surgery, the patient died 2 years later with local recurrence and metastasis to the lung and liver. In our case, after successful surgery and with regular follow-up, 2 years have passed and no recurrence or metastasis has been identified.…”

Primary Cutaneous Interdigitating Dendritic Cell Sarcoma

“…After the second surgery, no further recurrence was identified at 1 year follow-up visit. In the other case reported by Boldin et al, 4 after surgery, the patient died 2 years later with local recurrence and metastasis to the lung and liver. In our case, after successful surgery and with regular follow-up, 2 years have passed and no recurrence or metastasis has been identified.…”

Malignant Dendritic Cell Sarcomas in the Skin: 2 Cases of Rare Sarcoma Subtypes With Literature Review

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,5–11…”

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,[5][6][7][8][9][10][11] Histopathologically, PCIDCS neoplasms exhibit fascicular or storiform growth patterns with whorled spindle cells. 1 The tumor cells feature spindle or round nuclei, with vesicular chromatin, prominent eosinophilic nucleoli, and numerous mitoses.…”

“…Of the 10 cutaneous cases, 5 experienced local recurrence after excision and 3 of those died of metastatic disease. 2,3,5,7,8 Local disease may be effectively treated with wide local excision, although the appropriate margins are unclear. The patient in the first case underwent excision with a 1cm surgical margin, making it the only case documenting a measurement of excised surgical margin.…”

Mediastinal Follicular Dendritic Cell Sarcoma With Underlying Sjogren’s Syndrome

“…Monocytes and related-immune cells are divided into two types: (1) phagocytes, and (2) dendritic cells. The dendritic cells include follicular dendritic cells, interdigitating dendritic cells, intestinal dendritic cells, Langerhans cells, and indeterminate cells [ 6 ]. Follicular dendritic cells are mesenchymal-derived dendritic cells located in B-follicles, where they help trigger and maintain the B-cell adaptive immune response [ 1 ].…”

Primary Cutaneous Interdigitating Dendritic Cell Sarcoma

“…After the second surgery, no further recurrence was identified at 1 year follow-up visit. In the other case reported by Boldin et al, 4 after surgery, the patient died 2 years later with local recurrence and metastasis to the lung and liver. In our case, after successful surgery and with regular follow-up, 2 years have passed and no recurrence or metastasis has been identified.…”

Malignant Dendritic Cell Sarcomas in the Skin: 2 Cases of Rare Sarcoma Subtypes With Literature Review

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,5–11…”

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,[5][6][7][8][9][10][11] Histopathologically, PCIDCS neoplasms exhibit fascicular or storiform growth patterns with whorled spindle cells. 1 The tumor cells feature spindle or round nuclei, with vesicular chromatin, prominent eosinophilic nucleoli, and numerous mitoses.…”

“…Of the 10 cutaneous cases, 5 experienced local recurrence after excision and 3 of those died of metastatic disease. 2,3,5,7,8 Local disease may be effectively treated with wide local excision, although the appropriate margins are unclear. The patient in the first case underwent excision with a 1cm surgical margin, making it the only case documenting a measurement of excised surgical margin.…”

Mediastinal Follicular Dendritic Cell Sarcoma With Underlying Sjogren’s Syndrome

“…Monocytes and related-immune cells are divided into two types: (1) phagocytes, and (2) dendritic cells. The dendritic cells include follicular dendritic cells, interdigitating dendritic cells, intestinal dendritic cells, Langerhans cells, and indeterminate cells [ 6 ]. Follicular dendritic cells are mesenchymal-derived dendritic cells located in B-follicles, where they help trigger and maintain the B-cell adaptive immune response [ 1 ].…”

Primary Cutaneous Interdigitating Dendritic Cell Sarcoma

“…After the second surgery, no further recurrence was identified at 1 year follow-up visit. In the other case reported by Boldin et al, 4 after surgery, the patient died 2 years later with local recurrence and metastasis to the lung and liver. In our case, after successful surgery and with regular follow-up, 2 years have passed and no recurrence or metastasis has been identified.…”

Malignant Dendritic Cell Sarcomas in the Skin: 2 Cases of Rare Sarcoma Subtypes With Literature Review

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,5–11…”

“…Previous cases describing PCIDCS describe varying severity of disease, with about one-half of reported primary cases resulting in multiorgan metastasis, dissemination, and death. 2,3,[5][6][7][8][9][10][11] Histopathologically, PCIDCS neoplasms exhibit fascicular or storiform growth patterns with whorled spindle cells. 1 The tumor cells feature spindle or round nuclei, with vesicular chromatin, prominent eosinophilic nucleoli, and numerous mitoses.…”

“…Of the 10 cutaneous cases, 5 experienced local recurrence after excision and 3 of those died of metastatic disease. 2,3,5,7,8 Local disease may be effectively treated with wide local excision, although the appropriate margins are unclear. The patient in the first case underwent excision with a 1cm surgical margin, making it the only case documenting a measurement of excised surgical margin.…”

Mediastinal Follicular Dendritic Cell Sarcoma With Underlying Sjogren’s Syndrome

“…Monocytes and related-immune cells are divided into two types: (1) phagocytes, and (2) dendritic cells. The dendritic cells include follicular dendritic cells, interdigitating dendritic cells, intestinal dendritic cells, Langerhans cells, and indeterminate cells [ 6 ]. Follicular dendritic cells are mesenchymal-derived dendritic cells located in B-follicles, where they help trigger and maintain the B-cell adaptive immune response [ 1 ].…”