Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Seppey, Dominique; Sauser, Roger; Koenigsberger, M. Richard; Bény, Jean‐Louis; Meister, Jean-Jacques

doi:10.1152/ajpheart.00281.2009

Cited by 25 publications

(47 citation statements)

References 36 publications

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“…Oscillations are evoked by NE, KCl, or other agents that depolarize the E M (1333,1349). They are dependent on gap junctions and Cxs, notably Cx37 (981).…”

Section: E Vasomotionmentioning

confidence: 99%

Renal Autoregulation in Health and Disease

Carlström

Wilcox

Arendshorst

2015

Physiological Reviews

380

383

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Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80-180 mmHg). Such autoregulation is mediated largely by the myogenic and the macula densa-tubuloglomerular feedback (MD-TGF) responses that regulate preglomerular vasomotor tone primarily of the afferent arteriole. Differences in response times allow separation of these mechanisms in the time and frequency domains. Mechanotransduction initiating the myogenic response requires a sensing mechanism activated by stretch of vascular smooth muscle cells (VSMCs) and coupled to intracellular signaling pathways eliciting plasma membrane depolarization and a rise in cytosolic free calcium concentration ([Ca(2+)]i). Proposed mechanosensors include epithelial sodium channels (ENaC), integrins, and/or transient receptor potential (TRP) channels. Increased [Ca(2+)]i occurs predominantly by Ca(2+) influx through L-type voltage-operated Ca(2+) channels (VOCC). Increased [Ca(2+)]i activates inositol trisphosphate receptors (IP3R) and ryanodine receptors (RyR) to mobilize Ca(2+) from sarcoplasmic reticular stores. Myogenic vasoconstriction is sustained by increased Ca(2+) sensitivity, mediated by protein kinase C and Rho/Rho-kinase that favors a positive balance between myosin light-chain kinase and phosphatase. Increased RPP activates MD-TGF by transducing a signal of epithelial MD salt reabsorption to adjust afferent arteriolar vasoconstriction. A combination of vascular and tubular mechanisms, novel to the kidney, provides for high autoregulatory efficiency that maintains RBF and GFR, stabilizes sodium excretion, and buffers transmission of RPP to sensitive glomerular capillaries, thereby protecting against hypertensive barotrauma. A unique aspect of the myogenic response in the renal vasculature is modulation of its strength and speed by the MD-TGF and by a connecting tubule glomerular feedback (CT-GF) mechanism. Reactive oxygen species and nitric oxide are modulators of myogenic and MD-TGF mechanisms. Attenuated renal autoregulation contributes to renal damage in many, but not all, models of renal, diabetic, and hypertensive diseases. This review provides a summary of our current knowledge regarding underlying mechanisms enabling renal autoregulation in health and disease and methods used for its study.

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“…Oscillations are evoked by NE, KCl, or other agents that depolarize the E M (1333,1349). They are dependent on gap junctions and Cxs, notably Cx37 (981).…”

Section: E Vasomotionmentioning

confidence: 99%

Renal Autoregulation in Health and Disease

Carlström

Wilcox

Arendshorst

2015

Physiological Reviews

380

383

View full text Add to dashboard Cite

show abstract

“…More detailed models potentially can account for the spatial distribution of RyRs and IP 3 Rs and their differential compartmentalization with membrane channels, 161 a stochastic origin for the Ca 2+ oscillations, 200 the transition of unsynchronized intracellular Ca 2+ waves to global oscillations at the onset of vasomotion, 163 and for the intercellular Ca 2+ waves associated with propagation of vasomotion. 201 …”

Section: Vasomotionmentioning

confidence: 99%

Modeling Ca2+ Signaling in the Microcirculation: Intercellular Communication and Vasoreactivity

Kapela

Nagaraja

Parikh

et al. 2011

Crit Rev Biomed Eng

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A network of intracellular signaling pathways and complex intercellular interactions regulate calcium mobilization in vascular cells, arteriolar tone, and blood flow. Different endothelium-derived vasoreactive factors have been identified and the importance of myoendothelial communication in vasoreactivity is now well appreciated. The ability of many vascular networks to conduct signals upstream also is established. This phenomenon is critical for both short-term changes in blood perfusion as well as long-term adaptations of a vascular network. In addition, in a phenomenon termed vasomotion, arterioles often exhibit spontaneous oscillations in diameter. This is thought to improve tissue oxygenation and enhance blood flow. Experimentation has begun to reveal important aspects of the regulatory machinery and the significance of these phenomena for the regulation of local perfusion and oxygenation. Mathematical modeling can assist in elucidating the complex signaling mechanisms that participate in these phenomena. This review highlights some of the important experimental studies and relevant mathematical models that provide the current understanding of these mechanisms in vasoreactivity.

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“…For example, cyclic variations of the vascular diameter, called vasomotion, are induced by synchronous Ca 2þ oscillations of SMCs in which GJs are involved. 3 Before being incorporated into GJs, unapposed/nonjunctional Cx-hemichannels reside in the plasma membrane in a closed state. Accumulating evidence suggests that hemichannels can be opened by various messengers and conditions, thereby providing a conduit that allows the passage of ions and molecules with MW up to 1.5 kDa.…”

Section: Introductionmentioning

confidence: 99%

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

et al. 2016

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Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Abstract: Seppey D, Sauser R, Koenigsberger M, Bény JL, Meister JJ. Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips.

Cited by 25 publications

References 36 publications

Renal Autoregulation in Health and Disease

Renal Autoregulation in Health and Disease

Modeling Ca2+ Signaling in the Microcirculation: Intercellular Communication and Vasoreactivity

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

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