Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis

Cournu-Rebeix, Isabelle; Génin, Emmanuelle; Lesca, Gaëtan; Azoulay‐Cayla, Arièle; Tubridy, Niall; Noé, Eric; Clanet, M.; Edan, Gilles; Clerget‐Darpoux, Françoise; Sémana, G.; Fontaine, Bertrand

doi:10.1038/sj.gene.6364009

Cited by 29 publications

(20 citation statements)

References 38 publications

(42 reference statements)

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“…The gene encoding ICAM-1 is located on chromosome 19p13.2. Its polymorphic site K469E has been suggested to affect the function of ICAM-1 molecule (Iwao et al 2004) and influence the risk of inflammatory and autoimmune diseases (Cournu-Rebeix et al 2003;Lv et al 2012). Although our study failed to show the independent significant association between ICAM-1 K469E polymorphism and SSNHL, a synergistic effect was indicated between ICAM-1 K469E and IL-6 -572C/G in patients with SSNHL.…”

Section: Discussioncontrasting

confidence: 49%

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

Tian

Zhang

Yang

2018

Tohoku J. Exp. Med.

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Section: Discussioncontrasting

confidence: 49%

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

Tian

Zhang

Yang

2018

Tohoku J. Exp. Med.

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“…In addition, ICAM-1-dependent engagement and signaling in lymphocytes, blood-brain barrier endothelial cells, microglia, and astrocytes can activate effector mechanisms that promote the progression of neuroinflammation (10,21). Finally, genetic analyses have provided evidence of an association between a single nucleotide polymorphism in the ICAM-1 gene and MS development in several populations (22)(23)(24).…”

Section: Ultiple Sclerosis (Ms)mentioning

confidence: 99%

Intercellular Adhesion Molecule-1 Expression Is Required on Multiple Cell Types for the Development of Experimental Autoimmune Encephalomyelitis

Bullard¹,

Hu²,

Schoeb³

et al. 2007

The Journal of Immunology

123

103

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Many members of the Ig superfamily of adhesion molecules, such as ICAM-1 and VCAM-1, have been implicated in the pathogenesis of multiple sclerosis. Although it is well-established that VCAM-1/VLA-4 interactions can play important roles in mediating CNS inflammatory events in multiple sclerosis patients and during the development of experimental allergic encephalomyelitis (EAE), the contributions of ICAM-1 are poorly understood. This is due in large part to conflicting results from Ab inhibition studies and the observation of exacerbated EAE in ICAM-1 mutant mice that express a restricted set of ICAM-1 isoforms. To determine ICAM-1-mediated mechanisms in EAE, we analyzed ICAM-1 null mutant mice (ICAM-1null), which express no ICAM-1 isoforms. ICAM-1null mice had significantly attenuated EAE characterized by markedly reduced spinal cord T cell infiltration and IFN-γ production by these cells. Adoptive transfer of Ag-restimulated T cells from wild-type to ICAM-1null mice or transfer of ICAM-1null Ag-restimulated T cells to control mice failed to induce EAE. ICAM-1null T cells also showed reduced proliferative capacity and substantially reduced levels of IFN-γ, TNF-α, IL-4, IL-10, and IL-12 compared with that of control T cells following myelin oligodendrocyte glycoprotein 35–55 restimulation in vitro. Our results indicate that ICAM-1 expression is critical on T cells and other cell types for the development of demyelinating disease and suggest that expression of VCAM-1 and other adhesion molecules cannot fully compensate for the loss of ICAM-1 during EAE development.

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“…Polymorphisms of the ICAM-1 gene have previously been found to be significantly associated with rheumatoid arthritis [14] , inflammatory bowel disease [15] , melanoma [16] , Behçet's disease [17] , and multiple sclerosis [18] .…”

Section: Icam-1 and Il-6 Gene Polymorphism In Endometriosismentioning

confidence: 99%

Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

Chae

Lee

Choi³

et al. 2010

Gynecol Obstet Invest

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Background/Aims: The aim of this study was to investigate the possibility that the K469E and G241R polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene and the C-634G polymorphism in the interleukin (IL)-6 gene are associated with endometriosis in the Korean population. Methods: The ICAM-1 gene K469E and G241R polymorphisms and the IL-6 gene C-634G polymorphism were evaluated in 390 patients with endometriosis and 351 controls by polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The ICAM-1 gene G241R polymorphism was not observed in all subjects. No differences were observed in the ICAM-1 K469E and IL-6 C-634G genotype distributions and allele frequencies between patients with endometriosis and controls. In subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometriomas, no significant differences were observed in the ICAM-1 gene K469E or the IL-6 gene C-634G polymorphism frequencies between the subgroups and the controls. The combined analysis of the ICAM-1 gene K469E polymorphism and the IL-6 gene C-634G polymorphism did not show any additional significant findings. Conclusions: The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population.

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Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis

Cited by 29 publications

References 38 publications

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

Intercellular Adhesion Molecule-1 Expression Is Required on Multiple Cell Types for the Development of Experimental Autoimmune Encephalomyelitis

Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

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