Intercalative Ion‐Exchange Route to Amino Acid Layered Double Hydroxide Nanohybrids and Their Sorption Properties

Abstract

A soft chemical route to amino acid layered double hydroxide (LDH) nanohybrids was demonstrated on the basis of an intercalative ion-exchange reaction. Two different amino acids, phenylalanine and glutamic acid, were intercalated and stabilized in the interlayer space of a 2-dimensional double hydroxide lattice by electrostatic interaction. An attempt was also made to understand the effect of the intracrystalline structure of the amino acid in the LDH on the specific surface area, porosity, and gas sorption properties of the hybrid. According to the X-ray diffraction analysis, the basal spacings of LDH intercalated with phenylalanine and LDH intercalated with glutamic acid were expanded to 1.80 and 1.22 nm, respectively, relative to that of the pristine Mg 2 Al-NO 3 -LDH

2D Nanostructured Metal Hydroxides with Gene Delivery and Theranostic Functions; A Comprehensive Review

“…Moreover, the interlayer anions (A m− ) in LDHs can be replaced with various anions (A m− =Cl − , NO 3 − , CO 3 2− , SO 4 2− , organic or bioactive molecules, and etc.) depending upon the chemicals for synthesis or the biofunctional molecules to be coprecipitated, such as vitamins,, amino acids,, anticancer drugs, anti‐inflammatory drugs,, antibiotics,, and nucleotides including DNAs and RNAs, due to the anionic exchange property.…”

Layered double hydroxides, peculiar and versatile materials offering many research and application possibilities

“…Among the methods generally applied for this purpose [43] one can find wet chemical as well as mechanochemical techniques. The wet chemical methods can be direct anion exchange from water [44], aqueous ethanol or acetone [45]; co-precipitation of the components including the anion to be intercalated [46]; the dehydration-rehydration method of intercalation [47,48]. Occasionally, ultrasonic treatment increases the efficiency of the anion exchange or allows the introduction of anions, which would be difficult without its use [49,50].…”

Layered Double Hydroxide‐Based Functional Nanohybrids as Controlled Release Carriers of Pharmaceutically Active Ingredients

“…It can be concluded that the LDH host could be protecting the DNA bio‐molecules from their degradation and transport to exact target sites within the human body. Furthermore, anionic active drugs are also successfully intercalated into various LDH host families and the purpose of the active species is to regulate the viability of using these intercalated nanohybrids as carriers for transport, storage, and eventually for the control release of active molecules …”