2010
DOI: 10.1073/pnas.0914172107
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Abstract: The RNA world hypothesis proposes that nucleic acids were once responsible for both information storage and chemical catalysis, before the advent of coded protein synthesis. However, it is difficult to imagine how nucleic acid polymers first appeared, as the abiotic chemical formation of long nucleic acid polymers from mononucleotides or short oligonucleotides remains elusive, and barriers to achieving this goal are substantial. One specific obstacle to abiotic nucleic acid polymerization is strand cyclization… Show more

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Cited by 56 publications
(64 citation statements)
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“…ethidium bromide, that stabilize double strands, oligonucleotides up to 100 bp are formed, starting from concatenated tetrameric building blocks [20]. These authors demonstrated that a simple limitation of the cyclization pathway through the formation of relatively rigid double strands is enough to displace the equilibrium toward the formation of the long oligonucleotides.…”
Section: Formation Of Information-carrying Polymers Under Potentiallymentioning
confidence: 85%
See 1 more Smart Citation
“…ethidium bromide, that stabilize double strands, oligonucleotides up to 100 bp are formed, starting from concatenated tetrameric building blocks [20]. These authors demonstrated that a simple limitation of the cyclization pathway through the formation of relatively rigid double strands is enough to displace the equilibrium toward the formation of the long oligonucleotides.…”
Section: Formation Of Information-carrying Polymers Under Potentiallymentioning
confidence: 85%
“…The model system correlates with the work done by the groups of Orgel [18] and Hud [20]. In their systems, the decrease of the cyclization, resulting from the formation of double strands, leads to polymers formed by ligation of 10-20 building blocks.…”
Section: Discussionmentioning
confidence: 99%
“…The rate and extent of duplex assembly through oligonucleotide based ligation chemistry may be substantially increased by the presence of intercalating small molecules [46]. Intercalators can increase the effective affinity of short oligos for templates, acting in effect as a kind of glue that keeps an oligonucleotide substrate bound to a complementary template long enough for it to react with an adjacent monomer or oligonucleotide.…”
Section: Rate Of Template Copying Chemistrymentioning
confidence: 99%
“…Beyond a purely speculative model, dye molecules that intercalate DNA and RNA base pairs have been shown to promote the template-directed synthesis of nucleic acids. For example, intercalators can provide a .1000-fold enhancement to the ligation of short oligonucleotides (i.e., tri-and tetranucleotides) (Jain et al 2004), and promote a specific base pairing (Hud, Jain et al 2007;Horowitz et al 2010). …”
Section: Recent Resultsmentioning
confidence: 99%