Interatrial septal abnormalities and stroke

Overell, James; Bone, Ian; Lees, KR

doi:10.1212/wnl.55.8.1172

Cited by 892 publications

(691 citation statements)

References 45 publications

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“…5 This association between PFO and systemic and cerebral embolism or 'cryptogenic stroke' has been consistently supported, particularly in young adults less than 55 years old. 6 Aneyursmal atrial septum, large PFO size, and spontaneous passage of bubble contrast without provocative manoeuvres, as seen in our patient, have been cited as particular risk factors. 7 Transcatheter PFO closure has a low complication rate (o1%) and was first reported to reduce the risk of recurrent cryptogenic strokes in-patients with PFO in 1992.…”

Section: Commentsupporting

confidence: 58%

Central retinal artery occlusion: association with patent foramen ovale

Clifford

Sievers

Salmon

et al. 2005

Eye

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Section: Commentsupporting

confidence: 58%

Central retinal artery occlusion: association with patent foramen ovale

Clifford

Sievers

Salmon

et al. 2005

Eye

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“…Notably, most of our patients were aged less than 55 years and the association of PFO with cryptogenic stroke has been consistently reported in this age group [1]. Little data are available on the recurrence of cerebral ischaemic events (stroke/TIA) in patients with PFO and ASA.…”

Section: Discussionmentioning

confidence: 84%

“…In the last decade the role of patent foramen ovale (PFO) and atrial septal aneurysm (ASA) in the aetiopathogenesis of ischaemic stroke has been largely investigated [1]. Several studies have estimated the recurrence risk of stroke or transient ischaemic attack (TIA) in patients with PFO.…”

Section: Introductionmentioning

confidence: 99%

Recurrent cerebrovascular ischaemic events in patients with interatrial septal abnormalities: a follow-up study

et al. 2006

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The aim of this study was to evaluate the risk of recurrent ischaemic cerebrovascular events (stroke or transient ischaemic attack (TIA)) in patients with patent foramen ovale (PFO) or atrial septal aneurysm (ASA) treated with different therapeutic regimens. We enrolled 86 patients aged 18-60 years with an unexplained ischaemic stroke or TIA referred to our inpatient department in the period May 1994-December 1999. Follow-up lasted until April 2003. Patients were excluded if the stroke or TIA was related to large-artery atherosclerosis, small artery occlusion, major cardiac sources of embolism or other uncommon causes. During a follow-up (mean±SD) of 64.1±28.8 months (range 8.1-105.6) a recurrent ischaemic cerebrovascular event occurred in 11/86 patients (12.8%) (5 TIA and 6 strokes). Eight events (4 TIA, 4 strokes) occurred in the 59 patients with PFO alone, three (1 TIA, 2 strokes) in the 21 with PFO plus ASA and none in the 6 patients with ASA alone. In the overall population the cumulative risk of recurrent stroke/TIA was 1.2% at 2 years, 5.5% at 4 years, 7.6% at 6 years and 23.6% at 8 years, and was similar in patients with PFO alone vs. patients with PFO plus ASA (9.0% vs. 6.1% at 6 years, 26.0% vs. 23.1% at 8 years; p>0.05). Nine cerebral ischaemic events (4 TIA, 5 strokes) occurred in the 48 patients treated with antiplatelet drugs (7 in patients with PFO, 2 in patients with PFO plus ASA), and two (1 TIA, 1 stroke) in the 17 patients treated with oral anticoagulants (1 with PFO, 1 with PFO plus ASA). No events occurred in patients submitted to transcatheteral closure.

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“…The causal relationship between patent foramen ovale (PFO) and cryptogenic stroke has historically been controversial. Approximately 25% of the adult population has a PFO, and the condition by itself has not been shown to increase the risk of ischemic stroke 5, 6. Yet, the prevalence of PFO is significantly higher in patients with cryptogenic stroke; up to 40% of ischemic strokes without an identifiable cause have a PFO 7.…”

mentioning

confidence: 99%