2001
DOI: 10.1111/j.1574-6968.2001.tb10702.x
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Abstract: Escherichia coli strains of non-EPEC serotypes that carry eae and lack the EAF and the Shiga toxin (stx) gene sequences have been found in acute diarrhea. Both the cell association and the cell entry of these strains in human intestinal epithelial cells were studied as a function of cell differentiation and polarization. The eae+/EAF-/stx- non-EPEC E. coli strains invaded undifferentiated Caco-2 cells more efficiently than differentiated cells. In contrast, prototype EPEC strain E2348/69 did not show significa… Show more

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Cited by 15 publications
(9 citation statements)
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“…Similar observations have been made with bacteria infecting undifferentiated (non-polarized) eukaryotic cells [35,45]. These studies have shown a relationship between the differentiation stage of the particular host cells and the establishment of invasion [35,42,45]. Therefore, in order to examine whether aEPEC strains could also invade via the basolateral side of differentiated T84 cells, these cells were treated with different EGTA concentrations to open the epithelial tight junctions.…”
Section: Resultsmentioning
confidence: 64%
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“…Similar observations have been made with bacteria infecting undifferentiated (non-polarized) eukaryotic cells [35,45]. These studies have shown a relationship between the differentiation stage of the particular host cells and the establishment of invasion [35,42,45]. Therefore, in order to examine whether aEPEC strains could also invade via the basolateral side of differentiated T84 cells, these cells were treated with different EGTA concentrations to open the epithelial tight junctions.…”
Section: Resultsmentioning
confidence: 64%
“…Some studies have shown increased invasion indexes when cells are treated prior to infection with chemical agents that disrupt tight junctions and expose receptors on the basolateral side [35,45]. Similar observations have been made with bacteria infecting undifferentiated (non-polarized) eukaryotic cells [35,45]. These studies have shown a relationship between the differentiation stage of the particular host cells and the establishment of invasion [35,42,45].…”
Section: Resultsmentioning
confidence: 75%
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