1963
DOI: 10.1677/joe.0.0260031
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Abstract: Progesterone and various nor-steroids did not prevent oestrogenic interruption of early pregnancy in the mouse, although they inhibited other oestrogen-induced changes in the uterus and vagina. It is suggested that the relationship between oestrogen and progesterone is not one of simple molecular competition.

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Cited by 19 publications
(9 citation statements)
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References 15 publications
(20 reference statements)
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“…At other stages they act antagonistically, although Martin & Claringbold (1960) suggest that the antagonism occurs at the level of the secondary changes induced by the hormone. Martin (1963), however, showed that progesterone did not reverse the antifertility effect of oestrogen given before implantation, thus demon¬ strating a similar independence of action in what is probably a similar situation.…”
Section: Discussionmentioning
confidence: 93%
“…At other stages they act antagonistically, although Martin & Claringbold (1960) suggest that the antagonism occurs at the level of the secondary changes induced by the hormone. Martin (1963), however, showed that progesterone did not reverse the antifertility effect of oestrogen given before implantation, thus demon¬ strating a similar independence of action in what is probably a similar situation.…”
Section: Discussionmentioning
confidence: 93%
“…In the ovariectomized rat or mouse progesterone (P) substantially inhibits the rapid increases in RNA and protein accumulation and uterine weight that are seen in animals receiving large doses of oestrogen only (Roberts and Szego 1953;Martin 1963;Miller and Emmens 1969;Miller 1978). P also diminishes the cytosol concentration of specific, high-affinity 17 p-oestradiol (E 2 ) receptor in the uterus of these species, and several authors have suggested that the anti-oestrogenic or anti-uterotrophic activity of P may be mediated by this particular action of P on the E2 receptor (Bhakoo and Katzenellenbogen 1977;Clark et al 1977;Coulson and Pavlik 1977).…”
Section: Introductionmentioning
confidence: 99%
“…The interactions of oestradiol and progesterone in the uterus and vagina of rodents have been widely described but are not well understood (Courrier, 1950;Roberts & Szego, 1953 ;Martin, 1963). Much of the data available concerns changes in the weight and certain other parameters in the uterus, and in the appearance of vaginal smears after administration of the two hormones to ovariectomized animals (Edgren & Calhoun, 1957;Edgren, 1967).…”
Section: Introductionmentioning
confidence: 99%