Interactions and antioxidant stability of sesamol in dry-emulsions

Alencar, Juliana; Pietri, Sylvia; Culcasi, Marcel; Orneto, Caroline; Piccerelle, Philippe; Reynier, Jean-Pierre; Portugal, Henri; Nicolay, Alain; Kaloustian, J.

doi:10.1007/s10973-009-0102-8

Cited by 11 publications

(7 citation statements)

References 52 publications

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“…Sesamol has been found to reduce the activity of monoamine oxidase (MAO) and the generation of nitrite oxide and hydrogen peroxide in glial astrocytes. 11 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 Therefore, it has neuroprotective effects against cerebral ischemia. 29 MAO is an enzyme that catabolizes certain amines in the brain, such as serotonin, dopamine, and norepinephrine.…”

Section: Discussionmentioning

confidence: 99%

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The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

Turgut

Ergen

İlhan

2017

tjo

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Objectives:To investigate the potential protective effects of sesamol in an experimental cataract model.Materials and Methods:Twenty-one Spraque Dawley rat pups were randomly assigned into three groups, seven rats in each. All the rats except for those in the control group were injected subcutaneously with a single dose of sodium selenite on postpartum day 9. On days 10-14, rats in the sham group were intraperitoneally administered 50 mg/kg/day saline solution, while rats in the sesamol group were given 50 mg/kg/day sesamol by the same route. Following cataract grading, the lenses and capsules were extracted and the mean levels of reduced glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) in lens supernatants were biochemically analyzed.Results:The control group did not show any development of cataract. It was found that the mean cataract grade in the sesamol group was significantly lower than that of the sham group (p<0.05). The mean GSH level and TAS in the sesamol group were significantly higher than those of the sham group while the mean TOS and MDA level in the sesamol group were significantly lower than those of the sham group (p<0.05).Conclusion:Our study shows that sesamol reduces TOS and MDA level and increases TAS and GSH level in the lens and inhibits cataract formation.

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Section: Discussionmentioning

confidence: 99%

“…Sesamol has various important biological activities besides its strong antioxidant activity, such as induction of growth arrest and apoptosis in cancer and cardiovascular cells, enhancement of vascular fibrinolytic capacity, chemoprevention, and antimutagenic and antihepatotoxic activities. 11 …”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

Turgut

Ergen

İlhan

2017

tjo

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“…Thermal analysis: The DSC curve of the pure drug showed a sharp endothermic peat at 166. 26 In the suppository formulation, the sharp endothermic peak at 53.53 ºC indicated intermediate value of melting point of HPMC and bees wax (47.9 and 63 ºC, respectively) and the small peak at 142.89 ºC showed the Tg temperature of HPMC 31 . The melting point of the drug at 166.80 ºC was not modified in the formulation, which proved that there was no change in the solid state nature of the drug in addition to the polymers during the preparation.…”

Section: Mechanism Of Drug Release From the Suppositoriesmentioning

confidence: 98%

Innovation of Natural Product as Suppository Base

Devi¹,

Malarvizhi²,

Abinaya³

et al. 2014

Asian J. Chem.

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Indian system of traditional medicine has its unique position in the history of medicine. Similarly ghee's role as a medicament holds the same age, apart from its nutritional values it possesses best medicinal properties like enhancing the physical and mental strength and also in removing the impurities from our body. Ghee increases intelligence, memory power and the other uses include rejuvenation of skin, boosts body energy, detoxifies and nourishes body, increases clarity of voice, increases semen secretion, effective against eye disorders and wound healing activity, decreases the LDL cholesterol in plasma, increases gastric acid secretion for digestion and improves appetite 1-4. Suppositories are the solid dosage forms which can be inserted into the cavity of vagina or rectum or urethra for local or systemic effect, where it melts at body temperature and disperse or dissolve in cavity fluids to release the drug. Generally there are three types of suppositories namely vaginal, rectal and urethral suppositories. Semisolid bases act as a vehicle to carry drug which includes the fatty bases, water soluble bases, emulsion bases, hydrocarbon bases, that are selected based on the physicochemical properties of the drug and the desired therapeutic drug release effect. The specifications for an ideal base includes non-toxicity to tissues, non-irritation to mucous membranes, compatibility with variety of drugs, melting point range near to body temperature,

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“…Sesamol has been found to be an antioxidant and antifungal that can prevent the deterioration of fats. [52,53]…”

Section: Introductionmentioning

confidence: 99%

The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes

Topal

2019

International Journal of Food Properties

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Sesamol (1,3-benzodioxol-5-ol) is found in the oilseed product, sesame. In our study, the inhibitory effects of sesamol compound on acetylcholinesterase and α-glycosidase enzymes were evaluated. Another aim of this study was to compare the inhibitory effects of sesamol to acarbose for α-glycosidase enzyme and tacrine for acetylcholinesterase (AChE). Sesamol exhibited noncompetitive inhibition for both metabolic enzymes. IC 50 values for AChE and αglycosidase enzymes were calculated as 86.63 nM and 99.00 nM, respectively. On the other hand, K i values were calculated as 46.68 nM and 75.33 nM for AChE and α-glycosidase enzymes, respectively. According to the obtained results showed effective inhibition at low concentrations. ARTICLE HISTORY

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Interactions and antioxidant stability of sesamol in dry-emulsions

Cited by 11 publications

References 52 publications

The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

Innovation of Natural Product as Suppository Base

The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes

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